Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable bacterial product causes mutations in DNA that have been linked to colorectal cancer. Because it breaks down quickly, isolating and studying it has been difficult, but now scientists in the U.S. have discovered exactly how colibactin attacks DNA.
Using advanced tools such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, the team studied the toxin at the atomic level, as reported in a paper published in the journal Science...
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