Tregs tagged posts

Results from an early-stage clinical trial, published in Nature Communications, showed encouraging outcomes among patients with newly diagnosed cancer whose tumors had spread to distant organs. Most strikingly, one patient experienced a pathologic complete response—meaning no viable cancer cells could be found—and remains cancerfree for more than two years without further treatment. These findings offer an important signal that a new approach may be able to overcome one of the disease’s greatest challenges: its resistance to immunotherapy.

“We desperately need new tools in our arsenal,” said Gulam Manji, MD, PhD, a medical oncologist specializing in pancreatic cancer and lead investigator of the trial...

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators. The findings are poised to redirect lupus research and open the door to more precise therapies that avoid broad immune suppression.

Published in Nature Immunology, the study used single-cell RNA sequencing to profile CD4⁺ T-cell subtypes from children with SLE and healthy controls...

The mammalian immune system is an evolutionary wonder. It’s capable of recognizing and destroying cancer cells, and it can deploy armies of antibodies against viruses, bacteria, parasites and fungi.

Among the lesser-spotlighted roles of the immune system is how a particular T cell helps maintain homeostasis—fostering a balanced and stable metabolic environment—in fat cells. It’s a role that has captured the investigatory eye of an elite team of immunologists.

Having a stronger understanding of the dynamic metabolic activities and signaling pathways in fat tissue can aid new strategies to treat obesity, a major global health concern...

With insights into a molecular pathway that regulates the activity of Tregs, a type of T cell involved in immunosuppression, new research opens up possibly new avenues for treating inflammatory and autoimmune diseases.

Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection...