Cancer cells were treated with a control (left) and the overstimulating compound MCB-613 (right). Credit: Lei Wang
The demands of rapid cell division put a strain on cancer cells, and the approach works by tipping cell stress over the edge. Researchers show that the drug candidate inhibits tumor growth in a mouse model of breast cancer and efficiently kills a broad range of human cancer cells.
Because cancer cells acquire mutations in oncogenes to support their growth and survival, a great deal of research has focused on identifying oncogenes that could be targeted by cancer drugs...
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