The mysterious function of a key protein has been revealed following a breakthrough by University of Dundee scientists. HOIL-1 is a component of the Linear Ubiquitin Assembly Complex (LUBAC) which lies at the heart of the mechanism that determines whether the cells of our body will survive or die. Now researchers working in the laboratory of Professor Sir Philip Cohen in the University’s Medical Research Council Protein Phosphorylation Unit (MRC-PPU) have found that HOIL-1 operates in tandem with a second component of LUBAC to form ubiquitin chains.
The research, which has just been published in the journal Proceedings of the National Academy of Sciences (PNAS), has also revealed that the ubiquitin chains are joined to other protein...
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