UC tagged posts

Immune changes could signal inflammatory bowel disease up to 10 years before diagnosis

ulcerative colitis
Endoscopic image of a bowel section known as the sigmoid colon afflicted with ulcerative colitis. The internal surface of the colon is blotchy and broken in places. Credit: Samir/Wikipedia

A large-scale study, presented at UEG Week 2026, has identified distinct antibody patterns up to 10 years before the diagnosis of inflammatory bowel disease (IBD), potentially opening new avenues for earlier risk detection and providing insights into future disease course.

IBD is a group of chronic conditions, including Crohn’s disease (CD) and ulcerative colitis (UC), in which abnormal immune responses contribute to ongoing inflammation and damage in the digestive system...

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When Mucus can be Key Treating Colon and Airway diseases

New research at Malhotra lab reveals how cells control quantities of mucin released and could become a new avenue to treat several mucin-related diseases.

New research reveals how healthy cells in our bodies produce mucins – the main component of mucous, which protects our intestine and airway from pathogens, toxins and allergens. Scientists have already linked defects in mucins secretion to airway and colonic diseases, such as asthma or ulcerative colitis. Now, researchers at Malhotra’s laboratory in Barcelona, reveal how cells control quantities of mucin released and could become a new avenue to treat several mucin-related diseases.

Cells produce mucins at a constant rate, and when exposed to an allergen or pathogen, they produce more mucin in a rapid burst...

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