Cleavage of an RNA-containing D2C by an RCD.
New platform detects traces of everything from bacteria to viruses, cocaine and metals. DNA is best known as a genetic material, but is also a very programmable molecule that lends itself to engineering for synthetic applications. The new method shapes separately programmed pieces of DNA material into pairs of interlocking circles. The first remains inactive until it is released by the second, like a bicycle wheel in a lock. When the second circle, acting as the lock, is exposed to even a trace of the target substance, it opens, freeing the first circle of DNA, which replicates quickly and creates a signal, eg colour change.
“The key is that it’s selectively triggered by whatever we want to detect,” says Brennan, who holds the Canada Research Ch...
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