In red, highly proliferative cells of the intestinal crypts; they are targeted by irradiation and die during radiotherapy. They are considered to be radiosensitive. In green, dormant stem cells with high levels of URI; they survive irradiation, become proliferative after irradiation to regenerate the damaged intestine. /CNIO
Intensive radiotherapy can be toxic in 60% of patients with tumors located in the gastrointestinal cavity. Increases in levels of the protein URI protect mice against high-dose ionizing radiation-induced gastrointestinal syndrome and enhance mouse intestinal regeneration and survival in 100% of the cases...
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