wasabi receptor tagged posts

Scorpion Toxin that Targets ‘Wasabi Receptor’ may help Solve Mystery of Chronic Pain

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and PainCell, 2019; DOI: 10.1016/j.cell.2019.07.014

Researchers at UC San Francisco and the University of Queensland have discovered a scorpion toxin that targets the “wasabi receptor,” a chemical-sensing protein found in nerve cells that’s responsible for the sinus-jolting sting of wasabi and the flood of tears associated with chopping onions. Because the toxin triggers a pain response through a previously unknown mechanism, scientists think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.

The scientists isolated the toxin, a short protein (or peptide) that they dubbed the “wasabi receptor toxin” (W...

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