Category Biology/Biotechnology

COVID-19 Research: Study reveals New Details about Potentially Deadly Inflammation

COVID-19 research: New details about potentially deadly inflammation revealed in USC study
SARS-CoV-2 NSP14 facilitates the activation of NF-κB signaling and inflammatory response. a, HEK293T cells were transfected with the plasmids of 27 SARS-CoV-2 proteins, along with MyD88 and a reporter plasmid carrying the NF-κB promoter (NF-κB-Luc) and the cells were analyzed for NF-κB activity by reporter gene assay. The horizontal dashed line indicates the activation level of the positive control (EV+MyD88) group. b, Expression of the proinflammatory genes TNFA, IL1B, IL6 and IL8 in human MDMs transfected with NSP14-specific or scramble control (Ctrl) siRNA, followed with SARS-CoV-2 infection at MOI = 1 for 48 h. c, Expression of the proinflammatory genes from b in Dox-inducible SARS-CoV-2 NSP14-expressing THP-1 cells, measured after treatment with Dox (1 μg ml...
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Mechanism found to Determine Which Memories Last

CREDIT: GETTY/ANDRIY ONUFRIYENKO

Neuroscientists have established in recent decades the idea that some of each day’s experiences are converted by the brain into permanent memories during sleep the same night. Now, a new study proposes a mechanism that determines which memories are tagged as Important enough to linger in the brain until sleep makes them permanent.

Led by researchers from NYU Grossman School of Medicine, the study revolves around brain cells called neurons that “fire” – or bring about swings in the balance of their positive and negative charges — to transmit electrical signals that encode memories...

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Researchers Turn Sack the Clock on Cancer Cells to offer New Treatment Paradigm

First author Sandi Radko-Juettner, PhD, a former St. Jude Graduate School of Biomedical Sciences student, now a Research Program Manager for the Hematological Malignancies Program and senior author Charles W.M. Roberts, MD, PhD, Executive Vice President and St. Jude Comprehensive Cancer Center director.

St. Jude Children’s Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Findings showed that with the missing tumor suppressor, deleting or degrading the quality control protein DCAF5 reversed the cancer cell state...

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Consistently Exercising 2–3 times a week over the Long Term linked to Lower Current Insomnia Risk

active vs lazy
Credit: Unsplash/CC0 Public Domain

Consistently exercising 2–3 times a week over the long term is linked to a lower current risk of insomnia as well as the ability to clock up the recommended 6–9 hours of shut-eye every night, suggests an international 10-year study published in the open access journal BMJ Open.

Regular exercise is associated with better overall health, and several studies have suggested that physical activity promotes better quality sleep and may improve symptoms of chronic insomnia, note the researchers.

But it’s not entirely clear how much gender, age, weight (BMI), overall fitness, general health, and exercise type contribute to this association, they add.

To explore this further, the researchers assessed the frequency, duration, and intensity of weekl...

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