Category Biology/Biotechnology

Team develops Fluid Biomarker for Early Detection of Amyotrophic Lateral Sclerosis, ALS and Frontotemporal Dementia

Johns Hopkins Medicine-led team develops fluid biomarker for early detection of ALS and FTD
A Johns Hopkins Medicine-led team has developed a fluid biomarker that may one day detect two degenerative diseases, ALS and FTD, before symptoms appear. The biomarker locates a protein associated with the loss of function for the TDP-43 protein (seen as a molecular model in this image), an abnormality linked to people who develop ALS or FTD. Credit: Public domain image via Protopedia.org

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig’s disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning—the former affecting nerves in the brain and spinal cord ...

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Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses

T cell
Credit: Pixabay/CC0 Public Domain

Researchers from Children’s Hospital of Philadelphia (CHOP) identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

The findings also indicate that a better understanding of this metabolite and its role in immune response could improve the design of immunotherapies and create longer-lived responses against different types of cancer as well as enhance vaccine strategies. The findings were published online by the journal Science Immunology in a paper titled “Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics.”

Antigens are foreign substances that our ...

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World’s first N-Channel Diamond Field-Effect Transistor for CMOS Integrated Circuits

World's first N-channel diamond field-effect transistor for CMOS integrated circuits

A National Institute for Materials Science (NIMS) research team has developed the world’s first n-channel diamond MOSFET (metal-oxide-semiconductor field-effect transistor). The developed n-channel diamond MOSFET provides a key step toward CMOS (complementary metal-oxide-semiconductor: one of the most popular technologies in the computer chip) integrated circuits for harsh environment applications, as well as the development of diamond power electronics. The research is published in Advanced Science.

Semiconductor diamond has outstanding physical properties such as ultra wide-bandgap energy of 5...

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Neurobiologists Uncover how Stress turns into Fear in the Brain in Conditions such as PTSD

Our nervous systems are naturally wired to sense fear. Whether prompted by the eerie noises we hear alone in the dark or the approaching growl of a threatening animal, our fear response is a survival mechanism that tells us to remain alert and avoid dangerous situations.Read More