Category Biology/Biotechnology

A “dormant” brain protein turns out to be a powerful switch

Delta-type ionotropic glutamate receptors, or GluDs, are made of four GluD protein subunits that make a single receptor. The blue is D-serine, which is the neurotransmitter that activates the receptor
Delta-type ionotropic glutamate receptors, or GluDs, are made of four GluD protein subunits that make a single receptor. The blue is D-serine, which is the neurotransmitter that activates the receptor. Credit: Edward Twomey, Ph.D.

Researchers at Johns Hopkins Medicine report that they have uncovered a promising drug target that could allow scientists to increase or decrease the activity of specific brain proteins. The discovery may lead to new treatments for psychiatric conditions such as anxiety and schizophrenia, as well as a neurological disorder that affects movement and balance. The work was supported by funding from the National Institutes of Health.

The proteins at the center of the research are known as delta-type ionotropic glutamate receptors, or GluDs...

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Blood test can identify cancer in patients with non-specific symptoms

Blood test can identify cancer in patients with non-specific symptoms
Study populations and biomarker discovery workflow. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-67688-3

A simple blood test can help detect cancer in patients with non-specific symptoms such as fatigue, pain or weight loss. This is according to a Swedish study from Karolinska Institutet, Danderyd Hospital and others, published in Nature Communications.

When patients seek care for non-specific symptoms such as fatigue, pain or weight loss, it is often difficult to determine whether the cause is cancer, another serious condition or something completely harmless.

In a new study, researchers at Karolinska Institutet and Danderyd Hospital, together with Örebro University, KTH Royal Institute of Technology and SciLifeLab at Uppsala University, have investigated whet...

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A new robotic system could perform delicate eye surgery

A new robotic system could perform delicate eye surgery
Graphical abstract of the autonomous retinal vein cannulation workflow. Credit: Adapted from Zhang et al., Science Robotics (2025).

Retinal vein occlusion (RVO) is a severe disease that occurs when a vein in the light-sensitive layer at the back of the eye (i.e., the retina) becomes blocked, which results in a loss of vision. There are currently a few medical interventions that address RVO, including the periodic injection of medications that block the abnormal growth of blood vessels or of steroids, which reduce swelling and inflammation.

A promising procedure for the treatment of RVO is retinal vein cannulation (RVC)...

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A simple blood test could change how Alzheimer’s is diagnosed

blood test
Credit: Pixabay/CC0 Public Domain

A blood test, combined with an ultrathin material derived from graphite, could significantly advance efforts to detect Alzheimer’s disease at its very earliest stage, even before symptoms appear.

Alzheimer’s disease is the most common form of dementia. For millions of Europeans—and the health services that care for them—it is a ticking time bomb, with still no cure. But EU researchers are developing a simple tool to enable much earlier detection, potentially decades before symptoms appear.

Early detection matters because treatment is most effective when started as soon as possible. This gives people a better chance to slow the progression of the disease and plan for the future...

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