Category Biology/Biotechnology

Nutrients drive Cellular Reprogramming in the Intestine

A detailed summary of this study: the Drosophila adult midgut rapidly grows in size upon the first food intake after eclosion or upon refeeding after starvation. ©Hiroki Nagai et al.

Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation — where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.

Until now, dedifferentiation has primarily been associated with severe injuries or stressful conditions, observed during tissue regeneration and diseases like tumorigenesis...

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Bioengineered E. coli Generates Electricity from Wastewater

Bacteria generate electricity from wastewater
Flasks containing the electricity-producing E. coli. Credit: Jamani Caillet (EPFL)

In a breakthrough for the field of bioelectronics, researchers at EPFL have enhanced the ability of E. coli bacteria to generate electricity. The innovative approach offers a sustainable solution for organic waste processing while outperforming previous state-of-the-art technologies, opening new horizons for versatile microbial electricity production.

“We engineered E. coli bacteria, the most widely studied microbe, to generate electricity,” says Professor Ardemis Boghossian at EPFL. “Though there are exotic microbes that naturally produce electricity, they can only do so in the presence of specific chemicals. E...

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Exercise-induced Hormone Irisin may Reduce Alzheimer’s Disease Plaque and Tangle Pathology in the Brain

Reconstitution of amyloid plaques and NFT pathlogy. (Dooyeon Kim/Massachusetts General Hospital)

Medical researchers have used a 3D human neural cell culture model to show that the exercise-induced muscle hormone, irisin, reduces the level of amyloid beta deposits associated with Alzheimer’s disease.

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition — the generation of amyloid beta deposits followed by tau tangles — have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

As reported in the journal Neuron, the Massachusetts General Hospital (MGH)-led team has uncovered promising results suggesting that irisin-b...

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Red Blood Cells Exposed to Oxygen Deficiency Protect Against Myocardial Infarction

Red blood cells transport oxygen from the lungs to all the body’s cells. Photo: Getty Images

Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new KI study published in the Journal of Clinical Investigation. The study also shows that the protective effect is enhanced by a nitrate-rich vegetable diet.

Red blood cells carry oxygen from the lungs to all of the body’s cells and carbon dioxide back to the lungs. A new study, conducted at Karolinska Institutet in collaboration with Karolinska University Hospital, now shows that red blood cells have an intrinsic function of protecting against heart injury caused by myocardial infarction.

The effect is enhanced by a diet containing nitrate-rich vegetables, such as arugula and other green l...

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