Category Biology/Biotechnology

Uterine Fibroid Growth Activated by Phthalates, Chemicals found in Everyday Products

‘These toxic pollutants are everywhere, and their usage is not banned’. For the first time, scientists at Northwestern Medicine have demonstrated a causal link between environmental phthalates (toxic chemicals found in everyday consumer products) and the increased growth of uterine fibroids, the most common tumors among women.

Manufacturers use environmental phthalates in numerous industrial and consumer products, and they’ve also been detected in medical supplies and food. Although they are known to be toxic, they are currently unbanned in the U.S.

“These toxic pollutants are everywhere, including food packaging, hair and makeup products, and more, and their usage is not banned,” said corresponding study author Dr...

Read More

What happens to our Dopamine system when we Experience Aversive Events?

A new study at the Netherlands Institute for Neuroscience has examined how the dopamine system processes aversive unpleasant events.

It is well known that the dopamine system plays a crucial role in motivation, learning and movement. One of the main functions of dopamine is to predict the occurrence of rewarding experiences and the availability of rewards in our environment. In this context, the dopamine system informs our brains about so-called ‘reward prediction errors’ — the difference between received and predicted rewards. Dopamine neurons become more active when a reward occurs unexpectedly or if it is bigger than expected, and they show depressed activity when we receive less reward than predicted...

Read More

Designing and Programming Living Computers

Conceptual illustration: bacterial cells as artificial neural circuits

Transforming bacterial cells into living artificial neural circuits; applications include biomanufacturing and therapeutics. Bringing together concepts from electrical engineering and bioengineering tools, Technion and MIT scientists collaborated to produce cells engineered to compute sophisticated functions – “biocomputers” of sorts. Graduate students and researchers from Technion – Israel Institute of Technology Professor Ramez Daniel’s Laboratory for Synthetic Biology & Bioelectronics worked together with Professor Ron Weiss from the Massachusetts Institute of Technology to create genetic “devices” designed to perform computations like artificial neural circuits...

Read More

The Gut Microbiome’s Supersized Role in Shaping Molecules in our Blood

Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint). The difference between the two groups indicates a small, but nonetheless significant, overlap in variance explained by genetics and the microbiome. However, the variances explained by host genetics and the microbiome were largely additive. Stars denote significance (*** -p<0.001).
Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint)...
Read More