Category Biology/Biotechnology

OHSU Scientists Identify Molecule that could help Treat Parkinson’s

Locomotion activates PKA through dopamine and adenosine in striatal neurons  | Nature
: In vivo PKA activity imaging reveals cell-type-specific modulation of PKA by dopamine.

Discovery could immediately suggest new avenues for drug development. Researchers at Oregon Health & Science University have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control.

Scientists found that adenosine operates in a kind of push-pull dynamic with dopamine in the brain; the discovery published today in the journal Nature.

“There are two neuronal circuits: one that helps promote action and the other that inhibits action,” said senior author Haining Zhong, Ph.D., scientist with the OHSU Vollum Institute...

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New Hope for Patients with Severe Bone Loss

FmocFF/hyaluronic acid (HA) composite hydrogel formation and structural characterization. (a) Molecular structure of the FmocFF peptide. (b) Molecular structure of HA. (c) Inverted vials of FmocFF (left), FmocFF/HA composite hydrogel (middle) and HA (right). (d) Transmitting electron microscopy micrograph of the FmocFF/HA composite hydrogel. (e) Scanning electron microscopy micrograph of the FmocFF/HA composite hydrogel. (f) The FmocFF/HA composite hydrogel was formed in a 9 mm diameter × 2 mm depth silicone mould. (g) The FmocFF/HA composite hydrogel is injected through a 27-gauge needle. [Colour figure can be viewed at wileyonlinelibrary.com

Researchers induced bone regeneration with a special hydrogel that mimics the bone’s natural environment...

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Hormone discovery could Predict Long Term Health of Men

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Researchers have discovered the vital role of a hormone, that develops in men during puberty, in providing an early prediction of whether they could develop certain diseases in later life.

Scientists from the University of Nottingham have discovered that the novel insulin-like peptide hormone, called INSL3, is consistent over long periods of time and is an important early biomarker for prediction of age-linked disease. Their latest findings have been published today in Frontiers in Endocrinology.

INSL3 is made by the same cells in the testes that make testosterone, but unlike testosterone which fluctuates throughout a man’s life, INSL3 remains consistent, with the level at puberty remaining largely the same throughout a man’s life, decreasing only slightly into old age...

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Researchers develop a Material that Mimics how the Brain Stores Information

First artificial synapse that reproduces learning during sleep. Universitat Autònoma de Barcelona researchers have developed a magnetic material capable of imitating the way the brain stores information. The material makes it possible to emulate the synapses of neurons and mimic, for the first time, the learning that occurs during deep sleep.

Neuromorphic computing is a new computing paradigm in which the behavior of the brain is emulated by mimicking the main synaptic functions of neurons. Among these functions is neuronal plasticity: the ability to store information or forget it depending on the duration and repetition of the electrical impulses that stimulate neurons, a plasticity that would be linked to learning and memory.

Among the materials that mimic neuron synapses, me...

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