Glucocorticoid hormone signal in regulatory T cells promotes hair follicle stem cell activation and new hair growth. Left: After hair loss, skin cells (blue) from a normal mouse can activate hair follicle stem cells (red). Right: Cells from mice without glucocorticoid receptors in their regulatory T cells cannot activate hair follicle stem cells.
Study highlights how current treatments for alopecia work on a cellular level. Salk scientists have uncovered an unexpected molecular target of a common treatment for alopecia, a condition in which a person’s immune system attacks their own hair follicles, causing hair loss...
Plants are growing in complete darkness in an acetate medium that replaces biological photosynthesis. (Marcus Harland-Dunaway/UCR)
Scientists have found a way to bypass the need for biological photosynthesis altogether and create food independent of sunlight by using artificial photosynthesis. The technology, published in Nature Food, uses a two-step electrocatalytic process to convert CO2, electricity, and water into acetate ( main component if vinegar). Food-producing organisms then consume acetate in the dark to grow. The hybrid organic-inorganic system could increase the conversion efficiency of sunlight into food, up to 18x more efficient for some foods.
Photosynthesis has evolved in plants for millions of years to turn water, carbon dioxide, and the energy from sunlight into pl...
Dr. Guannan Wang performs intraductal injection under a microscope. Credit: Qinxin Jiang
Next step is to study in women receiving mastectomy. Delivering a targeted immunotoxin into breast ducts via openings in the nipple wiped out all visible and invisible precancerous lesions in laboratory studies, led by researchers at the Johns Hopkins Kimmel Cancer Center, of very early stage breast cancers.
A description of the work performed on mice, which the authors say provides a strong pre-clinical foundation for conducting feasibility and safety trials with patients who have stage 0 breast cancers, is published in the June 8 issue of the Proceedings of the National Academy of Sciences.
Stage 0 breast cancer, also known as ductal carcinoma in situ (DCIS), is characterized as the presenc...
Human lung epithelial cells (blue) infected by SARS-CoV-2 BA.2 virus (red) isolated from a patient with COVID-19 rebound after Paxlovid treatment.
Paxlovid rebound patient did not show drug resistance or impaired immunity. Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals. However, symptoms returned in some patients after treatment was completed, prompting the Centers for Disease Control and Prevention (CDC) to issue a health advisory on this so-called “COVID-19 rebound.”
In a study published June 20, 2022 in Clinical Infectious Diseases, researchers at University of California San Diego School of Medicine evaluated one such patient and found their symptom relapse was not caused by the development of resistance to the drug or im...
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