Category Biology/Biotechnology

Fast-acting Immune Cells provide Powerful Protection against Stroke

CREDIT: Adapted from Cai and Shi et al., 2022
CAPTION:  Within 24 hours after researchers depleted CD8+TRLs from the bloodstream of stroke mice, the size of the brain region affected by ischemia expanded by 50% (middle panel) compared to animals whose CD8+TRL levels remained intact (left and right panels).

CD8+ regulatory-like Tcells reach the brain within 24 hours after stroke onset, where they release molecules that provide direct neuroprotective effects, as well as limit inflammation and secondary brain damage.

“The beauty of CD8+TRLs is in their fast response. They confer very potent protection to the brain, which can last a long time,” said co-corresponding author Xiaoming Hu, M.D., Ph.D., associate professor of neurology at Pitt and a U.S...

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New link found that connects Cell Signaling Pathway to Development of Esophageal Cancers, Barrett’s Syndrome

Researchers believe pathway is a potential therapeutic target for gastroesophageal cancers. A team of researchers believe they have identified a cell signaling pathway responsible for the development of esophageal adenocarcinomas, an aggressive form of esophageal cancer that has gradually become more common, even in younger people.

Of the roughly 20,000 people in the U.S. diagnosed with esophageal cancer this year, just 4,000 are likely to still be alive in 2027. Such dire data has long driven researchers to try to understand the roots of the disease, but they have discovered little — until now.

“The incidence of esophageal cancers has increased several fold over the last few decades, making it the most common esophageal malignancy in the U.S...

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New Bioremediation Material can Clean ‘Forever Chemicals’

New bioremediation material can clean 'forever chemicals'
PFAS are adsorbed into the cell wall of the plant material. When the fungus consumes the plant, it also eats the chemical that was adsorbed. Credit: Susie Dai

A novel bioremediation technology for cleaning up per- and polyfluoroalkyl substances, or PFAS, chemical pollutants that threaten human health and ecosystem sustainability, has been developed by Texas A&M AgriLife researchers. The material has potential for commercial application for disposing of PFAS, also known as “forever chemicals.”

Published July 28 in Nature Communications, the research was a collaboration of Susie Dai, Ph.D., associate professor in the Texas A&M Department of Plant Pathology and Microbiology, and Joshua Yuan, Ph.D., chair and professor in Washington University in St...

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Harm from Blue Light Exposure Increases with Age, research in Flies suggests

Flies under blue light

The damaging effects of daily, lifelong exposure to the blue light emanating from phones, computers and household fixtures worsen as a person ages, new research by Oregon State University suggests.

The study, published today in Nature Partner Journals Aging, involved Drosophila melanogaster, the common fruit fly, an important model organism because of the cellular and developmental mechanisms it shares with other animals and humans.

Jaga Giebultowicz, a researcher in the OSU College of Science who studies biological clocks, led a collaboration that examined the survival rate of flies kept in darkness and then moved at progressively older ages to an environment of constant blue light from light-emitting diodes, or LEDs.

The darkness-to-light transitions occurred at the ages of...

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