Category Biology/Biotechnology

With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy—which involves strengthening the immune system to fight cancer—have proved disappointing. CAR-T cells are genetically modified immune cells manufactured in the laboratory and designed to identify and destroy cancer cells.

By targeting a protein present in the tumor environment, a team from the University of Geneva (UNIGE) and the Geneva University Hospital (HUG) has developed CAR-T cells capable of destroying glioblastoma cells. Their efficacy in an animal model of the disease paves the way for clinical trials in humans.

The results are published in the Journal for ImmunoTherapy of Cancer.

Glioblasto...

Mosses thrive in the most extreme environments on Earth, from the peaks of the Himalayas to the sands of Death Valley, the Antarctic tundra to the lava fields of active volcanoes. Inspired by moss’s resilience, researchers sent moss sporophytes—reproductive structures that encase spores—to the most extreme environment yet: space.

Their results, published in the journal iScience on November 20, show that more than 80% of the spores survived nine...

Temporarily anesthetizing the retina briefly reverts the activity of the visual system to that observed in early development and enables growth of responses to the amblyopic eye, new research shows.

In the common vision disorder amblyopia, impaired vision in one eye during development causes neural connections in the brain’s visual system to shift toward supporting the other eye, leaving the amblyopic eye less capable even after the original impairment is corrected. Current interventions are only effective during infancy and early childhood while the neural connections are still being formed.

But a new study in mice by neuroscientists in The Picower Institute f...

Researchers at Bar-Ilan University have discovered how the longevity-associated protein Sirt6 orchestrates a delicate molecular balancing act that protects the body from age-related decline and disease. The new findings, just published in the Proceedings of the National Academy of Sciences, reveal how Sirt6 preserves health during aging and may pave the way for therapies that promote a longer, healthier life.

Sirt6, often described as a master regulator of aging, is known for its powerful protective effects against age-related diseases such as cancer, diabete...