Category Biology/Biotechnology

AI-enabled ECGs may Identify Patients at Greater risk of Stroke, Cognitive Decline

Atrial fibrillation, the most common cardiac rhythm abnormality, has been linked to one-third of ischemic strokes, the most common type of stroke. But atrial fibrillation is underdiagnosed, partly because many patients are asymptomatic.

Artificial intelligence-enabled electrocardiography (ECG) was recently shown to identify the presence of brief episodes of atrial fibrillation, and the ability of an AI-enabled ECG algorithm to predict atrial fibrillation up to 10 years before clinical diagnosis has been confirmed in a population-based study conducted by Mayo Clinic researchers.

A new population-based study from Mayo Clinic now offers evidence that the algorithm can help identify patients at greater risk of cognitive decline...

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Researchers develop Smartphone-powered Microchip for At-Home Medical Diagnostic Testing

University of Minnesota researchers developed a new microfluidic chip with broad applications for detecting viruses, pathogens, bacteria and other biomarkers in liquid samples. Credit: Laboratory of Nanostructures and Biosensing, University of Minnesota

The new technology could make at-home diagnosis of diseases faster and more affordable. A University of Minnesota Twin Cities research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.

The researchers’ paper is published in Nature Communications, a peer-reviewed, open access, scientific journal published by Nature Research...

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How it works: The Protein that Stimulates Muscle Growth

Scientists say the discovery of a new function by cells known as astrocytes opens a whole new direction for neuroscience research. Illustration: Siena Fried

Research findings may help identify drug targets for neuromuscular disorders. Using genetic approaches, researchers have demonstrated how a certain protein is involved in skeletal muscle growth. The findings open new avenues to develop drug targets for neuromuscular diseases and other pathological conditions.

In the gym, you are not just pumping iron, you are oxygenating muscle cells which keeps those muscles healthy, strong and growing — a process called hypertrophy, or an increase in muscle mass due to an increase in muscle cell size. Conversely, under the covers, lounging, your muscles may begin to atrophy, or shrink.

Scie...

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RNA Binding Proteins help T cells pick their Weapons before Battle

Scientists at the Babraham Institute have shown that two RNA binding proteins hold the key to a stronger immune response to influenza in mice. Their findings, published today in Nature Communications, reveal that the absence of these proteins changes the potency of T cells that arise at the start on an infection. Further research could lead to implications for therapies that harness the immune system, and for vaccine design.

Researchers from the Turner lab focussed on the activity of the RNA binding proteins ZFP36 and ZFP36L1. By studying mice lacking these RNA binding proteins, the researchers were able to show that their absence in T cells during the initial phase of a viral infection leads to a superior cytotoxic immune response.

When the researchers infected mice with influe...

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