Category Biology/Biotechnology

Breakthrough Infections generate ‘Super Immunity’ to COVID-19, study suggests

Daniel Streblow, Ph.D., holds a plate of plasma samples that contain COVID-19 antibodies, to be evaluated in OHSUs in-house COVID-19 testing lab. Researchers have been studying antibody testing approaches. (OHSU/Kristyna Wentz-Graff)

Breakthrough infections greatly enhance immune response to variants of the virus that causes COVID-19, according to a newly published study from Oregon Health & Science University.

The laboratory results, published online ahead of print today in the Journal of the American Medical Association (JAMA), reveal that a breakthrough infection generates a robust immune response against the delta variant. Authors say the findings suggest the immune response is likely to be highly effective against other variants as the SARS-CoV-2 virus continues to mutate.

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Gallic Acid and Stretching Decrease Osteoarthritis Markers in Cartilage Cells

Image by Manuel Gonzalez Reyes on Pixabay

A healthy diet and a little exercise appear to be good for arthritis, even on the cellular level. A team led by Washington State University researchers used gallic acid, an antioxidant found in gallnuts, green tea and other plants, and applied a stretching mechanism to human cartilage cells taken from arthritic knees that mimics the stretching that occurs when walking. The combination not only decreased arthritis inflammation markers in the cells but improved the production of desired proteins normally found in healthy cartilage.

While still at an early stage, the findings suggest a new procedure could be developed to treat cartilage cells extracted from a patient to grow a supply of cells or a tissue to be re-implanted.

“We found the com...

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Uncovered: Key to how Exercise Protects against Consequences of Ageing

Staining showing mitochondria within individual muscle fibres. Credit: Monash University

Monash University, Australia scientists have discovered an enzyme that is key to why exercise improves our health. Importantly this discovery has opened up the possibility of drugs to promote this enzyme’s activity, protecting against the consequences of aging on metabolic health, including type 2 diabetes.

The proportion of people worldwide over 60 years old will double in the next three decades and by 2031, more than six million Australians will be over 65 years old. The incidence of type 2 diabetes increases with age so this aging population will also result in an increased incidence of the disease globally.

One of the main reasons for the increased prevalence of type 2 diabetes with age i...

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For Children, Young Adults with Recurrent AML, Immunotherapy Shows Promise

GARA ELIZABETH PHOTOGRAPHYResearchers at Washington University School of Medicine in St. Louis have shown, in a small clinical trial, that pre-activated natural killer cells can help some children and young adults with recurrent AML and few other treatment options. Pictured is Weston Robinett, 3, a patient who received this investigational therapy at Siteman Kids at St. Louis Children’s Hospital and Washington University School of Medicine. He remains in remission more than two years after treatment.

Natural killer cells could help young patients with few treatment options. An immunotherapy harnessing the immune system’s “natural killer” cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return...

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