Category Biology/Biotechnology

Cytokine APRIL Protects from Atherosclerotic Cardiovascular disease

Heart attacks and strokes are the main causes of death and loss of productive years globally. These clinical complications are caused by atherosclerosis, which is a chronic disease that leads to the accumulation of LDL cholesterol and immune cells in the inner layer of arteries and thereby resulting in the build-up of atherosclerotic plaques. Researchers from the Department of Laboratory Medicine of the Medical University of Vienna in collaboration with colleagues from the University of Lausanne (Switzerland) and the University of Cambridge (UK) have identified that a cytokine called A Proliferation Inducing Ligand (APRIL) plays a major protective role against the formation of atherosclerotic plaques. The study was now published in the journal Nature.

The investigators found that g...

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Scientists turn Pollen into 3D Printing Ink for Biomedical Applications

: Using pollen microgel as the support structure for freeform 3D printing, the
NTU scientists successfully fabricated a silicon elbow mesh.

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have found a way to use sunflower pollen to develop a 3D printing ink material that could be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery.

This pollen-derived ink is able to hold its shape when deposited onto a surface, making it a viable alternative to current inks used for 3D printing in the biomedical field (also known as bioprinting). Such inks are usually soft and delicate, making it a challenge to retain the final product’s desired 3D shape and structure as the bioprinter deposits the ink layer by layer.

To illustrate th...

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Widespread Tumor Suppression Mechanism Stops Cancer Progression by interfering with cancer cell Metabolism

Novel Parkin ubiquitome in cancer.(A) Bioinformatics analysis of predicted protein networks regulated by Parkin ubiquitination in the absence of mitochondrial uncoupling, including cell death (HK1, MCL1, and HMGB1), glucose metabolism involving glycolysis (HK1 and TPI1) and the PPP (TALDO1 and TKT), protein folding (CCT7 and HSPA1A, also known as HSP72), and mitochondrial dynamics (RHOT1, FIS1, and MFN2). Parkin-directed ubiquitination sites (Lys, K) identified by SILAC proteomics in each target protein are indicated. (B) PC3 cells in the presence or absence of Parkin were immunoprecipitated with an antibody to MFN2, and immune complexes were probed with antibodies to ubiquitin (Ub) or MFN2 by Western blotting. IP, immunoprecipitation; IB, immunoblot. (C) The conditions are as in (B) exce...
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Like venom coursing through the body: Researchers identify Mechanism driving COVID-19 Mortality

Students in white lab coats and safety gear stand around a microscope in Dr. Chilton's lab
In a photo taken prior to the pandemic, Dr. Chilton (second from left) and his lab team examine how genetic and epigenetic variations interact with human diets to drive inflammation and inflammatory disorders, as well as psychiatric and developmental disorders.Chris Richards/University of Arizona

An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation.

Researchers from the University of Arizona, in collaboration with Stony Brook University and Wake Forest University School of Medicine, analyzed blood samples from two COVID-19 patient cohorts and found that circulation of the enzyme – secreted p...

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