Category Biology/Biotechnology

Injectable Porous Scaffolds Promote Better, Quicker Healing after Spinal Cord Injuries

Images show myelinated axons in biomaterial scaffolds eight weeks after injection into the injured cord of a mouse. Scaffolds were fabricated from hyaluronic acid (HA) with a regular network of cell-scale macropores and loaded with gene therapy vectors encoding for brain-derived neurotrophic factor (BDNF), to promote axonal survival and regeneration. These were compared to control scaffolds, which were lacking the BDNF vector. Images show dense infiltration of cells (shown in blue, cell nuclei), axons (shown in red in A, NF200 protein) and myelinating glial cells (shown in green, myelin basic protein) in the BDNF-laden scaffolds. Scale bars = 200 µm. CREDIT: Seidlits et al.
Images show myelinated axons in biomaterial scaffolds eight weeks after injection into the injured cord of a mouse. 

Hydrogel scaffolds with regularly spaced pores encourage spinal cords cells to grow, improve regeneration of nerve cells. Researchers have developed materials that can interface with an injured spinal cord and provide a scaffolding to facilitate healing. To do this, scaffolding materials need to mimic the natural spinal cord tissue, so they can be readily populated by native cells in the spinal cord, essentially filling in gaps left by injury. The researchers show how the pores improve efficiency of gene therapies administered locally to the injured tissues, which can further promote tissue regeneration.

Spinal cord injuries can be life-changing and alter many importa...

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‘Wearable microgrid’ uses the human body to sustainably power small gadgets

White long sleeve shirt with electronics printed onto it
The wearable microgrid uses energy from human sweat and movement to power an LCD wristwatch and electrochromic device. Photos by Lu Yin

Nanoengineers at the University of California San Diego have developed a “wearable microgrid” that harvests and stores energy from the human body to power small electronics. It consists of three main parts: sweat-powered biofuel cells, motion-powered devices called triboelectric generators, and energy-storing supercapacitors. All parts are flexible, washable and can be screen printed onto clothing.

The technology, reported in a paper published Mar. 9 in Nature Communications, draws inspiration from community microgrids.

“We’re applying the concept of the microgrid to create wearable systems that are powered sustainably, reliably and independently...

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New Inhibitor found to combat Drug-resistant Cancer Cells

cancer
Credit: Pixabay/CC0 Public Domain

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells. The results were published in the scientific journal Molecules.

In addition to radiation therapy, cytotoxic agents, also known as chemotherapy, are frequently used to treat cancer. They prevent cells from dividing and thus cancer cells are unable to multiply unchecked...

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Reduced Heat Leakage Improves Wearable Health Device

Image of flexible device.
NC State’s flexible heat harvesting device shows better efficiency at retaining heat to power the device. Photo courtesy of Mehmet Ozturk.

North Carolina State University engineers continue to improve the efficiency of a flexible device worn on the wrist that harvests heat energy from the human body to monitor health.

In a paper published in npj Flexible Electronics, the NC State researchers report significant enhancements in preventing heat leakage in the flexible body heat harvester they first reported in 2017 and updated in 2020. The harvesters use heat energy from the human body to power wearable technologies — think of smart watches that measure your heart rate, blood oxygen, glucose and other health parameters — that never need to have their batteries recharged...

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