Category Biology/Biotechnology

The myriad processes occurring in biological cells may seem unbelievably complex at first glance. And yet, in principle, they are merely a logical succession of events, and could even be used to form digital circuits. Researchers have now developed a molecular switching circuit made of DNA, which can be used to mechanically alter gels, depending on the pH. DNA-based switching circuits could have applications in soft robotics, say the researchers in their article in Angewandte Chemie.

DNA is a long molecule that can be folded and twisted in various ways. It has a backbone and bases that stick out from the backbone and pair up with counterparts in other DNA strands...

Odor test spotted cancer with up to 95 percent accuracy. An odor-based test that sniffs out vapors emanating from blood samples was able to distinguish between benign and pancreatic and ovarian cancer cells with up to 95 percent accuracy, according to a new study from researchers at the University of Pennsylvania and Penn’s Perelman School of Medicine.

The findings suggest that the Penn-developed tool — which uses artificial intelligence and machine learning to decipher the mixture of volatile organic compounds (VOCs) emitting off cells in blood plasma samples — could serve as a non-invasive approach to screen for harder-to-detect cancers, such as pancreatic and ovarian.

The results ...

A new study published in Nature Communications demonstrates that a consortium of bacteria designed to complement missing or underrepresented functions in the imbalanced microbiome of inflammatory bowel disease (IBD) patients, prevented and treated chronic immune-mediated colitis in humanized mouse models. The study’s senior author, Balfour Sartor, MD, Midget Distinguished Professor of Medicine, Microbiology and Immunology, Co-Director of the UNC Multidisciplinary IBD Center, said the results are encouraging for future use treating Crohn’s disease and ulcerative colitis patients.

“The idea with this treatment is to restore the normal function of the protective bacteria in the gut, targeting the source of IBD, instead of treating its symptoms with traditional...

How to use glue and a high school 3D printer to create tiny implants for tissue engineering. Researchers have flipped traditional 3D printing to create some of the most intricate biomedical structures yet, advancing the development of new technologies for regrowing bones and tissue.

The emerging field of tissue engineering aims to harness the human body’s natural ability to heal itself, to rebuild bone and muscle lost to tumours or injuries.

A key focus for biomedical engineers has been the design and development of 3D printed scaffolds that can be implanted in the body to support cell regrowth.

But making these structures small and complex enough for cells to thrive remains a significant challenge.

Enter a RMIT University-led research team, collaborating with clinicians a...