Category Biology/Biotechnology

For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream. New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) provides insight into why this occurs, opening up new targets for treatments that could inhibit the spread of cancer.

The study, published today in Nature, found melanoma cells that pass through the lymph nodes pick up a protective coating, allowing them to survive high levels of oxidative stress in the blood and go on to form distant tumors.

Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitaminC in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo.

The findings by Oregon State University researchers were published in the journal Nutrients.

The research by scientists at OSU’s Linus Pauling Institute involved 42 healthy people ages 55 to 75 and was designed to measure the supplement’s effects on certain immune system indicators. It also looked at bloodstream levels of zinc and vitamins C and D while taking the supplement, as these micronutrients are important for proper immune function.

The immune indicators, including white blood cells’ ability to kill incoming pathogens, ...

A Rutgers-led team may have found the key to treating inflammatory diseases like asthma, allergies, chronic fibrosis and chronic obstructive pulmonary disease (COPD).

In a study published in the journal Nature Immunology, researchers discovered that neuromedin B (NMB), a protein produced by the nervous system, was responsible for preventing overactive immune responses and damaging inflammation. An immune response refers to the body’s ability to recognize and defend itself against harmful substances. Although beneficial to help clear infections, an immune response can also promote damaging inflammation if not properly restricted...

Doctors can predict patients’ risk for ischemic stroke based on the severity of their metabolic syndrome, a conglomeration of conditions that includes high blood pressure, abnormal cholesterol levels and excess body fat around the abdomen and waist, a new study finds.

The study found that stroke risk increased consistently with metabolic syndrome severity even in patients without diabetes. Doctors can use this information — and a scoring tool developed by a UVA Children’s pediatrician and his collaborator at the University of Florida — to identify patients at risk and help them reduce that risk.

“We had previously shown that the severity of metabolic syndrome was linked to future coronary heart disease and type 2 diabetes,” said UVA’s Mark DeBoer, MD...