Category Biology/Biotechnology

How Neurons Reshape inside Body Fat to boost its Calorie-Burning Capacity

sympathetic innervation of adipose tissue
Sparse neurons (left) in white fat, which stores calories, grow back after treatment with leptin (right).

Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue. Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future. There’s no doubt that you can lose fat by eating less or moving more – yet after decades of research, the biology underlying this equation remains mysterious. What really ignites the breakdown of stored fat molecules are nerves embedded in the fat tissue, and a new study now reveals that these fat-burning neurons have previously unrecognized powers. If they receive the right signal, they have an astonishing capacity to grow.

That signal...

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The Hair-raising Reason for Goosebumps

The hair follicle under the microscope, with the sympathetic nerve in green and the muscle in magenta.
Credit: Hsu Laboratory/Harvard University

The same cell types that cause goosebumps are responsible for controlling hair growth. If you’ve ever wondered why we get goosebumps, you’re in good company — so did Charles Darwin, who mused about them in his writings on evolution. Goosebumps might protect animals with thick fur from the cold, but we humans don’t seem to benefit from the reaction much — so why has it been preserved during evolution all this time?

In a new study, Harvard University scientists have discovered the reason: the cell types that cause goosebumps are also important for regulating the stem cells that regenerate the hair follicle and hair...

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New Nano Drug candidate kills Aggressive Breast Cancer cells

Chemical structure of multi-functional, anticancer drug candidate. Image provided by Hassan Beyzavi, University of Arkansas.

Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells. Triple negative breast cancer is one of the most aggressive and fatal types of breast cancer. The research will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy.

Their study was published in June issue of Advanced Therapeutics.

Researchers led by Hassan Beyzavi, assistant professor in the Department of Chemistry and Biochemistry, linked a new class of nanomaterials, called metal-organic frameworks, with the ligands of an already-developed photodynamic therapy dru...

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Could Mini-Neptunes be Irradiated Ocean Planets?

Mini-Neptune

New research suggests that the low density of mini-Neptunes could be explained simply by the presence of a thick layer of water. Many exoplanets known today are ‘super-Earths’, with a radius 1.3 times that of Earth, and ‘mini-Neptunes’, with 2.4 Earth radii. Mini-Neptunes, which are less dense, were long thought to be gas planets, made up of hydrogen and helium.

Now, scientists at the Laboratoire d’Astrophysique de Marseille (CNRS/Aix-Marseille Université/Cnes)(1) have examined a new possibility, namely that the low density of mini-Neptunes could be explained simply by the presence of a thick layer of water that experiences an intense greenhouse effect caused by the irradiation from their host star.

These findings, recently published in The Astrophysical Journal Let...

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