Yeast cells with the same DNA under the same environment show different structures of mitochondria (green) and the nucleolus (red), which may underlie the causes of different aging paths. Single and double arrowheads point to two cells with distinct mitochondrial and nucleolar morphologies.
Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan.
Our lifespans as humans are determined by the aging of our individual cells...
UIC’s Dr. Xiaoping Du oversees Ph.D. student Yaping Zhanga enter a sample in an aggregometer in his lab at the College of Medicine Research Building (Photo: Joshua Clark/University of Illinois at Chicago)
Peptide-derived nanoparticle shows promise in lab. Researchers at the University of Illinois at Chicago have developed a new drug that prevents blood clots without causing an increased risk of bleeding, a common side effect of all antiplatelet medications currently available.
A new study published in the journal Science Translational Medicine describes the drug and its delivery mechanisms and shows that the drug is also an effective treatment for heart attack in animal models.
Xiaoping Du, UIC professor of pharmacology and regenerative medicine at the College of Medicine, led ...
Image of changes in sections of the cecal mucosa based on combinations of low-fat diet (LFD), high-fat diet (HFD), with streptomycin (Strep) treatment
Combining Western diet and antibiotic use is a pre- IBD risk factor. UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre-inflammatory bowel disease (pre-IBD). The study, published July 14 in Cell Host and Microbe, suggests that this combination shutsdown the mitochondria in cells of the colon lining, leading to gut inflammation.
Irritable bowel syndrome (IBS) affects approximately 11% of people worldwide. It is characterized by recurring episodes of abdominal pain, bloating and changes in bowel habits...
Many anti-SARS-CoV-2 antibodies are produced by a common antibody gene. X-ray crystallography revealed how specific features of these antibodies (two of which are depicted here in yellow and orange, attached to the virus) enable potent recognition of the virus’s spike protein. Graphic by Meng Yuan, Hejun Liu and Nicholas Wu in the Wilson lab.
The findings support many vaccine strategies being used to tackle the new coronavirus. A team led by scientists at Scripps Research has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19.
The scientists, whose study appears July 13 in Science, reviewed data on nearly 300 anti-SARS-CoV-2 antibodies that their labs and others have found in convalescent COVID...
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