Category Biology/Biotechnology

Light-activated ‘CRISPR’ Triggers Precision Gene Editing and Super-fast DNA Repair

In a time-lapse video over eight hours, a high-powered microscope captures the moment when the CRISPR-Cas9 complex cuts two copies of a gene (red glow in blue circle and purple square) in a living cell. Scale Bar: 5 µm. Credit: Yang Liu, Johns Hopkins Medicine

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

Results of the experiments, published June 11 in Science, not only reveal new details about the DNA repair process, but also are likely, the researchers say, to speed up and aid understanding of the DNA a...

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‘Relaxed’ T Cells Critical to Immune Response

Rice University scientists’ simple model of T cell activation of the immune response shows the T cell binding, via a receptor (TCR) to an antigen-presenting cell (APC). If an invader is identified as such, the response is activated, but only if the “relaxation” time of the binding is long enough. Illustration by Hamid Teimouri

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: Quickly finding a few invaders among the many imposters in your body to trigger its immune response.

T cells have to react fast and do so nearly perfectly to protect people from diseases. But first, they need a little “me” time.

Rice University researchers suggest that has to do with how T cells “relax” in the process of binding to ligands—shor...

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Diluting Blood Plasma Rejuvenates Tissue, Reverses Aging in Mice

Older mice grew significantly more new muscle fibers, shown as pink “donut” shapes, after undergoing a procedure that effectively diluted the proteins in their blood plasma (bottom) than they did before they underwent the procedure (top). Credit: Irina Conboy

In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice—such that they share blood and organs—can rejuvenate tissues and reverse the signs of aging in the old mice. The finding sparked a flurry of research into whether a youngster’s blood might contain special proteins or molecules that could serve as a “fountain of youth” for mice and humans alike.

But a new study by the same team shows that similar age-reversing effects can be achieve...

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Beetle that can Survive in Volcanic Areas inspires new Cooling Materials

Photo of the fabricated Bio-RC film. Credit: University of Texas at Austin.

A type of beetle capable of regulating its body temperature in some of the hottest places on Earth is the centerpiece of new research with major potential implications for cooling everything from buildings to electronic devices in an environmentally friendly manner.

Researchers in the Cockrell School of Engineering at The University of Texas at Austin, with teams from Shanghai Jiao Tong University in China and KTH Royal Institute of Technology in Sweden, have discovered new information about a species of longicorn beetle that can cool its body enough to survive in volcanic areas in Southeast Asia...

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