Category Biology/Biotechnology

Protein in Mitochondria appears to Regulate Halth and Longevity

Having greater amounts of the peptide humanin is closely correlated with longer lives and better health in both animals and humans, including lower risk for Alzheimer’s.

A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.

The researchers examined humanin, a peptide encoded in the small genome of mitochondria — the powerhouses of the cell. From experiments in laboratory animals to measurements in human patients, the multi-site collaboration demonstrates how higher levels of humanin in the body are connected to longer lifespans and better health. It is linked to a lower risk for diseases such as Alzheimer’s.

“Humanin has long been known to...

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Far-UVC Light Safely Kills Airborne Coronaviruses, study finds

Equipment used to test the effect of far-UVC light on airborne coronaviruses. Photo: Center for Radiological Research at Columbia University.

More than 99.9% of seasonal coronaviruses present in airborne droplets were killed when exposed to a particular wavelength of ultraviolet light that is safe to use around humans, a new study at Columbia University Irving Medical Center has found.

“Based on our results, continuous airborne disinfection with far-UVC light at the current regulatory limit could greatly reduce the level of airborne virus in indoor environments occupied by people,” says the study’s lead author David Brenner, PhD, Higgins Professor of Radiation Biophysics at Columbia University Vagelos College of Physicians and Surgeons and director of the Center for Radiological Res...

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Origin of Life: Which Came First?

Proteins with primitive arginine-based proteins (right) might have been capable of self-assembly and phase separation to create cell-like droplets

An experiment in recreating primordial proteins solves a long-standing riddle. What did the very first proteins look like — those that appeared on Earth around 3.7 billion years ago? Prof. Dan Tawfik of the Weizmann Institute of Science and Prof. Norman Metanis of the Hebrew University of Jerusalem have reconstructed protein sequences that may well resemble those ancestors of modern proteins, and their research suggests a way that these primitive proteins could have progressed to forming living cells. Their findings were published in the Proceedings of the National Academy of Sciences (PNAS).

The proteins encoded in a cell’s genet...

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Hamsters develop protective Immunity to COVID-19 and are Protected by Convalescent Sera

Three x-rays of hamster lungs
Images of the lungs of hamsters before and after infection with SARS-CoV-2, from CT scans at UW Veterinary Care at the School of Veterinary Medicine. In blue are the trachea and bronchi. In red is a region of gas in the cavity just outside the lungs, indicating severe lung damage in the affected animal. The opaque clouding is similar to the “ground glass” appearance in the lungs of some human patients sick with COVID-19. Signs of severe disease in the lungs of hamsters became apparent within eight days of infection and began to improve by 10 days. The effects lingered for longer, as evident on the scan taken 16 days after initial infection. COURTESY OF YOSHIHIRO KAWAOKA

In an animal model for COVID-19 that shares important features of human disease, scientists at the University...

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