Category Biology/Biotechnology

Tiny Scorpion-derived Proteins deliver Arthritis Drugs to Joints in preclinical study

An Israeli death scorpion
More than a decade ago, Olson discovered a mini-protein found in the deathstalker scorpion that can bind to cancer cells but not healthy ones.Getty Images

Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.

“For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself,” said the project’s senior scientist Dr...

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A Flexible Brain for AI

Improved integration density: Comparison in integration density @[2020] IEEE. International Solid-State Circuits Conference

Scientists have developed a customizable computing device using nanofabricated switches than can be rewired to optimize AI applications using 80% less power. These devices can be used as flexible computing platform for artificial intelligence tasks.

Scientists at Osaka University built a new computing device from field-programmable gate arrays (FPGA) that can be customized by the user for maximum efficiency in artificial intelligence applications. Compared with currently used rewireable hardware, the system increases circuit density by a factor of 12. Also, it is expected to reduce energy usage by 80%...

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Yale Study may help Resolve Bitter Debate over Low-Cal Sweeteners

A diet soda with a green okay sign, and diet soda with fries under a red No sign
Illustration by Michael S. Helfenbein

A new study showed that people who periodically drank beverages with the low-calorie sweetener sucralose, which is found in low-cal soft drinks, candy, breakfast bars, and other products, did experience problematic metabolic and neural responses – but only when a carbohydrate in the form of a tasteless sugar was added to the drink. In contrast, people drinking beverages with low-calorie sweeteners alone, or beverages with real sugar, showed no changes in brain or metabolic response to sugars.

Several studies in recent years have reported that low-calorie sweeteners in foods and beverages disrupt the human , promoting the development of diabetes and obesity...

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Molecule found in Oranges could Reduce Obesity and prevent Heart disease and Diabetes

Researchers at Western University are studying a molecule found in sweet oranges and tangerines called nobiletin, which they have shown to drastically reduce obesity and reverse its negative side-effects. But why it works remains a mystery.

Researchers at Western University are studying a molecule found in sweet oranges and tangerines called nobiletin, which they have shown to drastically reduce obesity in mice and reverse its negative side-effects.

But why it works remains a mystery.

New research published in the Journal of Lipid Research demonstrates that mice fed a high-fat, high-cholesterol diet that were also given nobiletin were noticeably leaner and had reduced levels of insulin resistance and blood fats compared to mice that were fed a high-fat, high-cholesterol diet al...

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