Category Biology/Biotechnology

Viruses can Steal our Genetic Code to create new Human-Virus Genes

Highlights
d A mechanism of hybrid gene birth is employed by many
families of RNA viruses
d Human RNA and viral RNA encode new genes together
d Hybrid genes either make extensions of viral proteins or
novel proteins (UFOs)
d Human-virus genes and proteins play roles in pathogenesis
and are conserved

Like a scene out of “Invasion of the Body Snatchers,” a virus infects a host and converts it into a factory for making more copies of itself. Now researchers have shown that a large group of viruses, including the influenza viruses and other serious pathogens, steal genetic signals from their hosts to expand their own genomes.

This finding is presented in a study published online today and in print June 25 in Cell...

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Renewed Hope for Treatment of Pain and Depression

Fig. 3
SAR analysis of adrenorphin variants on ACKR3 and classical opioid receptors.

Novel molecule targets a newly discovered opioid receptor with atypical properties and holds promise for alternative therapeutic strategies.

Researchers at the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides produced in the central nervous system (CNS) and potentiating their natural painkilling and antidepressant properties...

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Sedentary Behavior Independently predicts Cancer Mortality

Replacing sitting time with 30 minutes of activity associated with lower risk of cancer death. In the first study to look at objective measures of sedentary behavior and cancer mortality, researchers from The University of Texas MD Anderson Cancer Center found that greater inactivity was independently associated with a higher risk of dying from cancer. The most sedentary individuals had an 82% higher risk of cancer mortality compared to the least sedentary individuals. An accelerometer was used to measure physical activity, rather than relying on participants to self-report their activity levels

“This is the first study that definitively shows a strong association between not moving and cancer death,” said Susan Gilchrist, M.D...

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Light-activated ‘CRISPR’ Triggers Precision Gene Editing and Super-fast DNA Repair

In a time-lapse video over eight hours, a high-powered microscope captures the moment when the CRISPR-Cas9 complex cuts two copies of a gene (red glow in blue circle and purple square) in a living cell. Scale Bar: 5 µm. Credit: Yang Liu, Johns Hopkins Medicine

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

Results of the experiments, published June 11 in Science, not only reveal new details about the DNA repair process, but also are likely, the researchers say, to speed up and aid understanding of the DNA a...

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