Category Biology/Biotechnology

‘Relaxed’ T Cells Critical to Immune Response

Rice University scientists’ simple model of T cell activation of the immune response shows the T cell binding, via a receptor (TCR) to an antigen-presenting cell (APC). If an invader is identified as such, the response is activated, but only if the “relaxation” time of the binding is long enough. Illustration by Hamid Teimouri

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: Quickly finding a few invaders among the many imposters in your body to trigger its immune response.

T cells have to react fast and do so nearly perfectly to protect people from diseases. But first, they need a little “me” time.

Rice University researchers suggest that has to do with how T cells “relax” in the process of binding to ligands—shor...

Read More

Diluting Blood Plasma Rejuvenates Tissue, Reverses Aging in Mice

Older mice grew significantly more new muscle fibers, shown as pink “donut” shapes, after undergoing a procedure that effectively diluted the proteins in their blood plasma (bottom) than they did before they underwent the procedure (top). Credit: Irina Conboy

In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice—such that they share blood and organs—can rejuvenate tissues and reverse the signs of aging in the old mice. The finding sparked a flurry of research into whether a youngster’s blood might contain special proteins or molecules that could serve as a “fountain of youth” for mice and humans alike.

But a new study by the same team shows that similar age-reversing effects can be achieve...

Read More

Beetle that can Survive in Volcanic Areas inspires new Cooling Materials

Photo of the fabricated Bio-RC film. Credit: University of Texas at Austin.

A type of beetle capable of regulating its body temperature in some of the hottest places on Earth is the centerpiece of new research with major potential implications for cooling everything from buildings to electronic devices in an environmentally friendly manner.

Researchers in the Cockrell School of Engineering at The University of Texas at Austin, with teams from Shanghai Jiao Tong University in China and KTH Royal Institute of Technology in Sweden, have discovered new information about a species of longicorn beetle that can cool its body enough to survive in volcanic areas in Southeast Asia...

Read More

Super-potent Human Antibodies protect against COVID-19 in Animal Tests

A human antibody (blue) attaches to the receptor binding domain (red) on the SARS-CoV-2 virus. (Model courtesy of the Burton lab.)

Scientists isolate powerful coronavirus-neutralizing antibodies from COVID-19 patients and successfully test in animals. A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus that causes the disease, when tested in animals and human cell cultures.

The research, published today in Science, offers a paradigm of swift reaction to an emergent and deadly viral pandemic, and sets the stage for clinical trials and additional tests of the antibodies, which are now being produced as potential treatments and preventives for COVID-19.

“The discover...

Read More