Category Biology/Biotechnology

There’s a long-held belief in diabetes prevention that weight loss is the main way to lower disease risk. Our new study challenges this.

For decades, people diagnosed with prediabetes—a condition affecting up to one in three adults depending on age—have been told the same thing by their doctors: eat healthily and lose weight to avoid developing diabetes.

This approach hasn’t been working for all. Despite unchanged medical recommendations for more than 20 years, diabetes prevalence continues rising globally. Most people with prediabetes find weight-loss goals hard to reach, leaving them discouraged and still at high risk of diabetes.

Our latest research, published in Nature Medicine, reveals a different approach entirely...

Research led by the Max Planck Institute for Biology of Aging in Cologne reports that misincorporation of ribonucleotides into mitochondrial DNA (mtDNA) initiates an inflammatory cascade.

Mitochondria support cell survival through metabolic and signaling roles. Conversely, their disruption has been associated with inflammation, cell death and disease.

Innate immune activation through the cGAS-STING-TBK1 pathway can move a cell from short-term defense to a chronic state of alarm. cGAS-STING activity is linked to autoimmune and inflammatory diseases and contributes to senescence and aging, intertwining immune signaling with tissue decline.

Senescent cells then adopt a secretor...

People who sleep poorly are more likely than others to have brains that appear older than they actually are. This is according to a comprehensive brain imaging study from Karolinska Institutet, published in the journal eBioMedicine. The paper is titled “Poor sleep health is associated with older brain age: the role of systemic inflammation.”

Increased inflammation in the body may partly explain the association.

Poor sleep has been linked to dementia, but it is unclear whether unhealthy sleep habits contribute to the development of dementia or whether they are rather early symptoms of the disease.

In a new study, researchers at Karolinska Institutet have investigated the link between sleep characteristics and how old the brain appears in relat...

Scientists digging through data collected by the Cassini spacecraft have found new complex organic molecules spewing from Saturn’s moon Enceladus. This is a clear sign that complex chemical reactions are taking place within its underground ocean. Some of these reactions could be part of chains that lead to even more complex, potentially biologically relevant molecules.

Published in Nature Astronomy, this discovery further strengthens the case for a dedicated European Space Agency (ESA) mission to orbit and land on Enceladus.

In 2005, Cassini found the first ...