Category Biology/Biotechnology

‘Smart’ Bandages Heal Chronic Wounds

Illustration of the
A UConn researcher has helped develop a new “smart bandage” that could improve clinical care. (courtesy of Dr. Ali Tamayol)

Chronic and non-healing wounds – one of the most devastating complications of diabetes and the leading cause of limb amputation – affects millions of Americans each year. Due to the complex nature of these wounds, proper clinical treatment has been limited.

For the first time, faculty in the biomedical engineering department – a shared department with the UConn School of Dental Medicine, School of Medicine, and School of Engineering – designed a wirelessly-controlled, or “smart,” bandage and corresponding smartphone-sized platform that can precisely deliver different medications to the wound with independent dosing.

This bandage, developed by Dr...

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‘Multitasking’ AI Tool to Extract Cancer Data in record time

The image visualizes how the team’s multitask convolutional neural network classifies primary cancer sites. Image credit: Hong-Jun Yoon/ORNL
The image visualizes how the team’s multitask convolutional neural network classifies primary cancer sites. Image credit: Hong-Jun Yoon/ORNL

To better leverage cancer data for research, scientists are developing an artificial intelligence (AI)-based natural language processing tool to improve information extraction from textual pathology reports. In a first for cancer pathology reports, the team developed a multitask convolutional neural network (CNN) – a deep learning model that learns to perform tasks, such as identifying key words in a body of text, by processing language as a two-dimensional numerical dataset.

As the second-leading cause of death in the United States, cancer is a public health crisis that afflicts nearly one in two people during their lifetime...

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Scientists Reverse Reproductive Clock in Mice

SIRT2 Transgenic Mice Have Improved Oocyte Quality

Researchers have lifted fertility rates in older female mice with small doses of a metabolic compound that reverses the aging process in eggs, offering hope for some women struggling to conceive.

The University of Queensland study found a non-invasive treatment could maintain or restore the quality and number of eggs and alleviate the biggest barrier to pregnancy for older women.

A team led by UQ’s Professor Hayden Homer found the loss of egg quality through aging was due to lower levels of a particular molecule in cells critical for generating energy.
“Quality eggs are essential for pregnancy success because they provide virtually all the building blocks required by an embryo,” Professor Homer said.

“We investigated whether...

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Pedal to the metal: Speeding up Treatments for ALS

TDP-43 is the red protein being expressed in yeast. Some of it is being sent to inside an organelle called the vacuole in yeast (lysosome in humans), which is the blue circle. Buchan describes the lysosome as the trash compactor/recycling depot of the cell that endocytosis and autophagy send their substrates too. (Courtesy: Ross Buchan)
TDP-43 is the red protein being expressed in yeast. Some of it is being sent to inside an organelle called the vacuole in yeast (lysosome in humans), which is the blue circle. Buchan describes the lysosome as the trash compactor/recycling depot of the cell that endocytosis and autophagy send their substrates too. (Courtesy: Ross Buchan)

A therapeutic intervention for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig’s disease, could be on the horizon thanks to unexpected findings by University of Arizona researchers.

ALS is the progressive degeneration of motor neurons that causes people to lose the ability to move and eventually speak, eat and breathe.

Within the neuronal cells of patients with ALS and other neurodegenerative diseases, two proteins – TDP-43 and FUS – a...

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