Category Biology/Biotechnology

First Supercentenarian-derived Stem Cells Created

Induced pluripotent stem cells (iPSCs) can transform into any cell in the body
Induced pluripotent stem cells (iPSCs) can transform into any cell in the body.

People who live more than 110 years, called supercentenarians, are remarkable not only because of their age, but also because of their incredible health. This elite group appears resistant to diseases such as Alzheimer’s, heart disease and cancer that still affect even centenarians. However, we don’t know why some people become supercentenarians and others do not.

Now, for the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPSCs)...

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Statins Starve Cancer Cells to Death

Dictyostelium Amoeba, the same species used in the initial drug screen Credit: xiaoguang Li

More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. Now, in experiments with human cells in the laboratory, researchers at Johns Hopkins Medicine have added to growing evidence that the ubiquitous drug may kill cancer cells and have uncovered clues to how they do it.

The findings, say the researchers, enhance previous evidence that statins could be valuable in combating some forms of cancer. In unrelated studies, other Johns Hopkins Medicine researchers have studied how statins may cut the risk for aggressive prostate cancer.

“There have been epidemiological indications that people who take statins long term have fewer and less aggressive cance...

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Popular Painkiller Ibuprofen affects Liver Enzymes in Mice

Pills spilling from a bottle
Ibuprofen is a widely used and important drug, but is known to have effects on the heart. New research from UC Davis shows that ibuprofen has multiple, unexpected effects on liver metabolism in mice that differ between males and females. (Getty Images)

Marked differences between males and females. The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis. The study in laboratory mice also shows marked differences between males and females.

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, widely used over the counter to treat pain and fever...

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‘Natural Killer’ Cells could halt Parkinson’s Progression

‘Natural killer’ cells could halt Parkinson’s progression
March 12, 2020
by Charlene Betourney
Left, imaging of healthy neurons from mouse brain. Right, imaging of damaged neurons by PD protein clumps. (Images courtesy of the Lee Lab)

Researchers at the University of Georgia’s Regenerative Bioscience Center and their colleagues have found that “natural killer” white blood cells could guard against the cascade of cellular changes that lead to Parkinson’s disease and help stop its progression.

Natural killer (NK) cells are white blood cells that can kill tumors without being “told” from the body to do so...

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