Category Biology/Biotechnology

Parkinson’s Disease may start Before Birth

Clive Svendsen, PhD, director of the Cedars-Sinai Board of Governors Regenerative Medicine Institute, right, and Nur Yucer, PhD, a project scientist, discuss a microscope image of dopamine neurons. Photo by Cedars-Sinai.

Stem cell study finds malfunctioning brain cells in patients who were diagnosed before age 50; researchers test potential new treatment. People who develop Parkinson’s disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes.

Parkinson’s occurs when brain neurons that make dopamine, a substance that helps coordinate muscle movement, become impaired or die...

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New Light Shed on Damaging Impact of Infrared and Visible Rays on Skin

Professor Mark Birch-Machin in the lab

The damage visible and infrared light can do to our skin has been revealed for the first time in new research by scientists at Newcastle University, UK.

The detrimental effects of exposure to the sun’s rays are well documented, and the main aim of sunscreens is to protect the skin against dangerous ultraviolet radiation (UV).

However, experts at Newcastle University have now scientifically proven that UV rays are not the only type that can penetrate deep into the skin, as visible and infared light can also harm our skin’s cells.

The study, published online today in The FASEB Journal, reveals that the deeper dermal layer of the skin is damaged by UV, visible and infared light and that it may be beneficial for anti-ageing to protect our s...

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Novel Communication between Intestinal Microbes and developing Immune Cells in the Thymus

Early life entero-thymic communication: Complex interplay between intestinal microbes, host TLR2, pDCs and developing cells in the thymus 

Regulation of thymic immune development by intestinal microbes in early life. Researchers discover microbes regulate the development of specialized immune cells in the thymus that play a critical role in mucosal tolerance.

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of foreign antigens, the major burden of which is in the form of the microbiota newly colonizing the gastrointestinal tract...

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‘Jumping Genes’ help Stabilize DNA Folding Patterns

Fig. 2
Contribution of TEs to the conservation landscape of human and mouse loops. a Flowchart describing the methodology used to annotate loop orthology. b Venn diagram representing the various classes of chromatin loops based on their orthology and bar plots showing the contribution of REs to anchor CTCFs of each class of loops. c Age distribution and age of individual TEs that contribute loop anchor CTCF sites (black dots for orthologous loops; gold dots for non-orthologous loops) (left), total contribution to loop anchor CTCF sites (middle), distribution of orthologous and non-orthologous loops (right) derived from the top 13 TE subfamilies in mouse and d humans. Estimated primate/rodent divergence time (82 million years ago) is from Meredith et al. [47]. e Contact maps representing a conse...
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