Category Biology/Biotechnology

Paper-based Test could diagnose Lyme disease at early stages

Point-of-Care Serodiagnostic Test for Early-Stage Lyme Disease Using a Multiplexed Paper-Based Immunoassay and Machine Learning

After a day hiking in the forest, the last thing a person wants to discover is a tick burrowing into their skin. Days after plucking off the bloodsucking insect, the hiker might develop a rash resembling a bull’s-eye, a tell-tale sign of Lyme disease. Yet not everybody who contracts Lyme disease gets the rash. Now, researchers reporting in ACS Nano have devised a blood test that quickly and sensitively diagnoses the disease at early stages.

About 300,000 cases of Lyme disease, which is caused by the tick-borne bacteria Borrelia burgdorferi, are diagnosed in the U.S. each year, according to the U.S. Centers for Disease Control and Prevention...

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Artificial Intelligence identifies previously unknown features associated with Cancer Recurrence

Illustration showing structure of the disk
Outline of the method. First, unsupervised deep neural networks were applied to pathology images without being taught any medical knowledge. Next, the features (a series of numbers that humans cannot directly understand) acquired by AI were translated into high-resolution images that can be understood by humans and were automatically assigned optimum weights to make images interpretable.

Artificial intelligence (AI) technology developed by the RIKEN Center for Advanced Intelligence Project (AIP) in Japan has successfully found features in pathology images from human cancer patients, without annotation, that could be understood by human doctors...

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High-Tech Method for uniquely Targeted Gene Therapy developed

Selective activation of basolateral amygdala projections to the rostromedial striatum induced using the MNM004 capsid drives fear and anxiety phenotypes. 

Neuroscientists at Lund University in Sweden have developed a new technology that engineers the shell of a virus to deliver gene therapy to the exact cell type in the body that needs to be treated. The researchers believe that the new technology can be likened to dramatically accelerating evolution from millions of years to weeks.

Several of the new revolutionary treatments that have been used clinically in recent years to treat complex diseases – such as spinal muscular atrophy and enzyme deficiency – are based on gene therapy.

With gene therapy, the genetic material is controlled or altered using biological drugs...

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Hydrogels Control Inflammation to Help Healing

An illustration shows how effective a selection of custom-designed peptide hydrogels are in controlling inflammation. The gels developed at Rice University serve as scaffolds for new tissue and show promise for treating wounds and cancer and for delivering drugs. The hydrogels are designed to dissolve in the body as they are replaced by natural, functional tissue. Illustration by Tania Lopez-Silva

Scientists model how synthetic gels can tune body’s inflammatory response. Hydrogels for healing, synthesized from the molecules up by Rice University bioengineers, are a few steps closer to the clinic.

Rice researchers and collaborators at Texas Heart Institute (THI) have established a baseline set of injectable hydrogels that promise to help heal wounds, deliver drugs and treat cancer...

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