Category Biology/Biotechnology

‘Primitive’ Stem Cells shown to Regenerate Blood Vessels in the Eye

Human vascular progenitor cells (green), made from Zambidis’ lab-grown naive stem cells, engraft into blood vessels (red) in a mouse retina. Credit: Elias Zambidis, Johns Hopkins Medicine

Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.

“Our study results bring us a step closer to using stem cells more widely in regenerative medicine, without the historical problems...

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Repurposed Drugs may help scientists Fight the New Coronavirus


M protease (model shown) is a key enzyme for the new corona­virus’ survival and may be an Achilles’ heel. Drugs (blue) might be able to nestle into the enzyme and stop viral replication. DAVID S. GOODSELL/RCSB PROTEIN DATA BANK

Work on similar viruses is giving researchers clues to develop drugs against the disease. As the new coronavirus makes its way around the world, doctors and researchers are searching for drugs to treat the ill and stop the spread of the disease, which has already killed more than 3,800 people since its introduction in Wuhan, China, in December.

The culprit virus is in the same family as the coronaviruses that caused two other outbreaks, severe acute respiratory syndrome and Middle East respiratory syndrome...

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Tiny Scorpion-derived Proteins deliver Arthritis Drugs to Joints in preclinical study

An Israeli death scorpion
More than a decade ago, Olson discovered a mini-protein found in the deathstalker scorpion that can bind to cancer cells but not healthy ones.Getty Images

Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.

“For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself,” said the project’s senior scientist Dr...

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A Flexible Brain for AI

Improved integration density: Comparison in integration density @[2020] IEEE. International Solid-State Circuits Conference

Scientists have developed a customizable computing device using nanofabricated switches than can be rewired to optimize AI applications using 80% less power. These devices can be used as flexible computing platform for artificial intelligence tasks.

Scientists at Osaka University built a new computing device from field-programmable gate arrays (FPGA) that can be customized by the user for maximum efficiency in artificial intelligence applications. Compared with currently used rewireable hardware, the system increases circuit density by a factor of 12. Also, it is expected to reduce energy usage by 80%...

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