Category Biology/Biotechnology

Dietary Zinc protects against Streptococcus pneumoniae infection, study finds

These are elemental bio-images of mouse lungs during Streptococcus pneumoniae infection. The image shows increased zinc levels (orange to red regions) mobilised by the innate immune response to sites where the bacteria has invaded.
CREDIT:
Philip A. Doble and Christopher A. McDevitt

Researchers have uncovered a crucial link between dietary zinc intake and protection against Streptococcus pneumoniae, the primary bacterial cause of pneumonia. Globally, it is estimated that nearly two billion people suffer from zinc deficiency, but why this increases susceptibility to bacterial infection has not been well understood – until now.

University of Melbourne Associate Professor Christopher McDevitt, a laboratory head at the Doherty Institute, led an interdisciplinary team using state-of-the-...

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Scorpion Toxin that Targets ‘Wasabi Receptor’ may help Solve Mystery of Chronic Pain

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and PainCell, 2019; DOI: 10.1016/j.cell.2019.07.014

Researchers at UC San Francisco and the University of Queensland have discovered a scorpion toxin that targets the “wasabi receptor,” a chemical-sensing protein found in nerve cells that’s responsible for the sinus-jolting sting of wasabi and the flood of tears associated with chopping onions. Because the toxin triggers a pain response through a previously unknown mechanism, scientists think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.

The scientists isolated the toxin, a short protein (or peptide) that they dubbed the “wasabi receptor toxin” (W...

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Australian Men’s Life Expectancy Tops Other Men’s

Michel Guillot, Collin F. Payne. Tracking progress in mean longevity: The Lagged Cohort Life Expectancy (LCLE) approachPopulation Studies, 2019; DOI: 10.1080/00324728.2019.1618480

Australian men are now living longer than any other group of males in the world, according to new research from The Australian National University (ANU). The study introduces a new way of measuring life expectancy, accounting for the historical mortality conditions that today’s older generations lived through. By this measure, Australian men, on average, live to 74.1.

The news is good for Australian women too; the study shows they’re ranked second, behind their Swiss counterparts.

Dr Collin Payne co-led the study, which used data from 15 countries across Europe, North America and Asia with high life...

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Antibiotic use linked to heightened Bowel Cancer risk but lower rectal cancer risk, suggesting differences in microbiome activity

Image result for Antibiotic use linked to heightened bowel cancer risk
Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989–2012: a matched case–control study, Gut (2019). DOI: 10.1136/gutjnl-2019-318593

Antibiotic use (pills/capsules) is linked to a heightened risk of bowel (colon) cancer, but a lower risk of rectal cancer, and depends, to some extent, on the type and class of drug prescribed, suggests research published online in the journal Gut.

The findings suggest a pattern of risk that may be linked to differences in gut microbiome (bacteria) activity along the length of the bowel and reiterate the importance of judicious prescribing, say the researchers.

In 2010, patients around the world took an estimated 70 billion doses of antibiotics – equivalent to 10 doses each...

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