Category Biology/Biotechnology

High-Fat Diet and Gut Bacteria Linked to Insulin Resistance

Gut-associated IgA immune cells regulate obesity-related insulin resistance. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11370-y

Researchers have discovered how our choice of diet can weaken our gut immune system and lead to the development of diabetes. A growing body of research supports that during obesity, our immune system is often responding to components of bacteria that “leak” through the intestinal tissue and results in inflammation. In turn, inflammation can drive insulin resistance, which predisposes people to diabetes.

In new research published in Nature Communications this week, Dr...

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Robotic Neck Brace dramatically Improves Functions of ALS patients

A study participant wearing the neck brace.

Comfortable brace incorporates both sensors and actuators to restore roughly 70% of the active range of motion. A novel neck brace, which supports the neck during its natural motion, was designed by Columbia engineers. This is the first device shown to dramatically assist patients suffering from Amyotrophic Lateral Sclerosis (ALS) in holding their heads and actively supporting them during range of motion. This advance would result in improved quality of life for patients, not only in improving eye contact during conversation, but also in facilitating the use of eyes as a joystick to control movements on a computer, much as scientist Stephen Hawkins famously did.

A team of engineers and neurologists led by Sunil Agrawal, professor of mecha...

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Inherited Pancreatic Cancer Risk Mutation Identified

Pancreatic Cancer Histology

The discovery of the previously unknown mutation could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3. Scientists studying a highly cancer-prone family have identified a rare, inherited gene mutation that dramatically raises the lifetime risk of pancreatic and other cancers.

The discovery of the previously unknown mutation, reported in Nature Genetics by investigators from Dana-Farber/Brigham and Women’s Cancer Center, could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3...

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New ‘Liquid Biopsy’ Blood Test improves Breast Cancer Diagnostics

ctDNA analysis in patients with early and locally advanced breast cancer before treatment and after completion of NAT.

Test could help avoid unnecessary surgeries; enable physicians to continuously monitor cancer. A new type of blood test for breast cancer could help avoid thousands of unnecessary surgeries and otherwise precisely monitor disease progression, according to a study led by the Translational Genomics Research Institute (TGen) and Mayo Clinic in Arizona.

TGen is an affiliate of City of Hope, which along with The Cancer Research UK Cambridge Institute at Cambridge University and the Biodesign Institute at Arizona State University (ASU) also contributed to this study.

Published today in the premier journal Science Translational Medicine, the study suggests that the te...

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