Category Biology/Biotechnology

Key Proteins for the Repair of Nerve Fibers Identified

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS

Scientists at the German Center for Neurodegenerative Diseases (DZNE) have identified a group of proteins that help to regenerate damaged nerve cells. Their findings are reported in the journal Neuron.

It is commonly accepted that neurons of the central nervous system shut down their ability to grow when they no longer need it; this occurs normally after they have found their target cells and established synapses. However, recent findings show that old nerve cells have the potential to regrow and to repair damage similar to young neurons...

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Novel Nano-Vaccine for Melanoma

Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0

Injection of Nanoparticle has proven effective in Mouse Models, researchers say. Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer. Their innovative approach has so far proven effective in preventing the development of melanoma in mouse models and in treating primary tumors and metastases that result from melanoma.

The focus of the research is on a nanoparticle that serves as the basis for the new vaccine. The study was led by Prof...

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How Deep Space Travel could affect the Brain

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Radiation exposure alters the electrophysiological properties of neurons in the hippocampus. The image is credited to Acharya et al., eNeuro 2019.

Radiation exposure impairs learning and memory, causes anxiety. Exposure to chronic, low dose radiation – the conditions present in deep space – causes neural and behavioral impairments in mice, researchers report in eNeuro. These results highlight the pressing need to develop safety measures to protect the brain from radiation during deep space missions as astronauts prepare to travel to Mars.

Radiation is known to disrupt signaling among other processes in the brain. However, previous experiments used short-term, higher dose-rate exposures of radiation, which does not accurately reflect the conditions in space.

To investigate how d...

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Researchers find Proteins that might Restore Damaged Sound-Detecting Cells in the Ear

Mouse cochlea with hair cells shown in green and auditory nerves shown in red. Credit: Doetzlhofer lab

Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as hair cells, are born in the mammalian inner ear. The proteins, described in a report published June 12 in eLife, may hold a key to future therapies to restore hearing in people with irreversible deafness.

“Scientists in our field have long been looking for the molecular signals that trigger the formation of the hair cells that sense and transmit sound,” says Angelika Doetzlhofer, Ph.D., associate professor of neuroscience at the Johns Hopkins University School of Medicine...

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