Category Biology/Biotechnology

How we make Complex Decisions

MIT neuroscientists are exploring how the brain handles hierarchical decision-making processes that involve breaking down a larger decision into smaller ones that each carry a degree of uncertainty.
Image: Chelsea Turner, MIT

Neuroscientists identify a brain circuit that helps break decisions down into smaller pieces. The study sheds light on how the brain reasons about probable causes of failure after a hierarchy of decisions. When making a complex decision, we often break the problem down into a series of smaller decisions. For example, when deciding how to treat a patient, a doctor may go through a hierarchy of steps – choosing a diagnostic test, interpreting the results, and then prescribing a medication.

Making hierarchical decisions is straightforward when the sequence of cho...

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Wearable Cooling and Heating Patch could serve as personal Thermostat and Save Energy

Prototype of the cooling and heating patch embedded in a mesh armband. Photos by David Baillot/UC San Diego Jacobs School of Engineering

Engineers at the University of California San Diego have developed a wearable patch that could provide personalized cooling and heating at home, work, or on the go. The soft, stretchy patch cools or warms a user’s skin to a comfortable temperature and keeps it there as the ambient temperature changes. It is powered by a flexible, stretchable battery pack and can be embedded in clothing. Researchers say wearing it could help save energy on air conditioning and heating.

“This type of device can improve your personal thermal comfort whether you are commuting on a hot day or feeling too cold in your office,” said Renkun Chen, a professor of mechanical an...

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A New Way of Diagnosing and Treating Disease – without cutting Skin

Imaging blood vessel before and after closure.(A and C) RCM and STD images of the same blood vessel before and after closure. (B) Algorithm of STD. N is the frame number for calculation of STD (in this case, N = 10); Ixy(i) is the pixel (x,y) intensity in the ith frame; Uxy is the average intensity at pixel (x,y) over all frames. (D to G) STD of different sized blood vessels before (top row) and after (bottom row) closure. The dashed white square boxes indicate the scanning irradiation area of the high-power treatment fs laser on the vessels. The pulse energy is 4.5 nJ per pulse, and the irradiation time is in the range of 0.1 to 2.1 s. Scale bars, 50 μm. (See movies S1 and S2 for more details.)

Researchers develop new laser microscope that could be ‘revolutionary’ for treatment of ...

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Newly identified Bacteria-killing Protein needs Vitamin A to work


Highlights

Skin microbiota induces epidermal RELMα, which kills bacteria via membrane disruption
RELMα-deficient mice have altered skin microbiota and are more susceptible to infection
Dietary vitamin A is required for RELMα expression
RELMα is required for vitamin-A-dependent resistance to skin infection

People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. In a study published today, UT Southwestern researchers shed some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work.

The researchers found that one protein in the resistin-like molecule (RELM) family – RELMα – acts as an antibiotic to rapidly kill...

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