Category Biology/Biotechnology

CRISPR-Cas3 innovation holds promise for Disease Cures, advancing science

The new system, called CRISPR-Cas3, can efficiently erase long stretches of DNA from a targeted site in the human genome, a capability not easily attainable in more traditional CRISPR-Cas9 systems. (stock image)
Credit: © MG / Fotolia

A Cornell researcher, who is a leader in developing a new type of gene editing CRISPR system, and colleagues have used the new method for the first time in human cells – a major advance in the field.

The new system, called CRISPR-Cas3, can efficiently erase long stretches of DNA from a targeted site in the human genome, a capability not easily attainable in more traditional CRISPR-Cas9 systems...

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CRISPR-based ‘allelic drive’ allows Genetic Editing with Selective Precision and Broad Implications

Left panel: Gene-drive is mediated by a guide RNA (gRNA) that cuts at the exact site (scissors) where the gene-drive element (blue box: Cas9 gene; yellow box: gRNA) is inserted into the genome, resulting in full gene-drive element copying. Right panel: The new allelic drive is accomplished by the addition of a second gRNA (blue box) to a gene drive element that preferentially cuts a detrimental allele (scissors), but not the beneficial allele, resulting in beneficial allele copying.
Credit: Bier Lab, UC San Diego

Scientists developed a new version of a gene drive that allows the spread of specific, favorable genetic variants, also known as ‘alleles,’ throughout a population...

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Gum Bacteria implicated in Alzheimer’s and other diseases

Bacteria involved in periodontitis have been linked with Alzheimer’s disease, aspiration pneumonia, rheumatoid arthritis and other common disorders. The image is credited to Jan Potempa, University of Louisville.

Scientists trace path of bacterial toxins from the mouth to the brain and other tissues. Researchers are reporting new findings on how bacteria involved in gum disease can travel throughout the body, exuding toxins connected with Alzheimer’s disease, rheumatoid arthritis and aspiration pneumonia. They detected evidence of the bacteria in brain samples from people with Alzheimer’s and used mice to show that the bacterium can find its way from the mouth to the brain.

The bacterium, Porphyromonas gingivalis, is the bad actor involved in periodontitis, the most serious for...

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Cold Plasma can Kill 99.9% of Airborne Viruses

Civil and Environmental Engineering Professor Herek Clack (left) and members of his team set up a lab-scale non-thermal plasma device that has previously been proven to achieve greater than 99% inactivation of an airborne viral surrogate, MS2 phage, a virus that infects E.coli bacteria at the Barton Farms family pig farm in Homer, MI. Image credit: Robert Coelius/Michigan Engineering
Civil and Environmental Engineering Professor Herek Clack (left) and members of his team set up a lab-scale non-thermal plasma device that has previously been proven to achieve greater than 99% inactivation of an airborne viral surrogate, MS2 phage, a virus that infects E.coli bacteria at the Barton Farms family pig farm in Homer, MI. Image credit: Robert Coelius/Michigan Engineering

Dangerous airborne viruses are rendered harmless on-the-fly when exposed to energetic, charged fragments of air molecules, University of Michigan researchers have shown. They hope to one day harness this capability to replace a century-old device: the surgical mask.

The U-M engineers have measured the virus-killing speed and effectiveness of nonthermal plasmas – the ionized, or charged, particles that...

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