Category Biology/Biotechnology

A boundary dance of Amyloid-beta stepping into Dementia

(a) An A-beta peptide that forms a beta-hairpin structure at the hydrophilic/hydrophobic interface. (b) View from the bottom of panel (a).
Credit: ExCELLS/IMS

Formation mechanism of the causative substances of Alzheimer’s disease revealed. Alzheimer’s disease is caused by aggregates of amyloid-beta peptides. This aggregation is accelerated at a cell membrane surface. The research group at ExCELLS revealed the reason of this phenomenon by molecular dynamics simulations and NMR experiments.

Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils...

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How Exercise Reduces Belly Fat in humans

This graphical abstract shows that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling.
CREDIT
Wedell-Neergaard, Lehrskov, and Christensen, et al. / Cell Metabolism

Some of you may have made a New Year’s resolution to hit the gym to tackle that annoying belly fat. But have you ever wondered how physical activity produces this desired effect? A signaling molecule called interleukin-6 plays a critical role in this process, researchers report December 27 in the journal Cell Metabolism.

As expected, a 12-week intervention consisting of bicycle exercise decreased visceral abdominal fat in obese adults...

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Sustainable ‘Plastics’ are on the Horizon


Macroalgal biomass subcritical hydrolysates for the production of polyhydroxyalkanoate (PHA) by Haloferax mediterranei

New sustainable biopolymer technology may one day free the world of its worst pollutant. A new Tel Aviv University study describes a process to make bioplastic polymers that don’t require land or fresh water – resources that are scarce in much of the world. The polymer is derived from microorganisms that feed on seaweed. It is biodegradable, produces zero toxic waste and recycles into organic waste.

The invention was the fruit of a multidisciplinary collaboration between Dr. Alexander Golberg of TAU’s Porter School of Environmental and Earth Sciences and Prof. Michael Gozin of TAU’s School of Chemistry...

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Salk Scientists find Genetic Signatures of Biological Aging

Fig. 1

Predicting age from gene expression data. Rows from top to bottom show age prediction results for LDA Ensemble with 20-year age bins, elastic net, linear regression, and support vector regression

Some people appear to be considerably younger or older than their chronological age. Genetic signatures that may help explain this have been discovered by scientists at the Salk Institute. The age-associated genetic patterns were found by analyzing skin cells from people of various ages, according to a study by Salk Institute scientists.

Researchers then applied the results to detect genetic signs of accelerated aging in people with progeria, a disease that causes patients to appear far older than their chronological age...

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