Category Biology/Biotechnology

Salk Scientists find Genetic Signatures of Biological Aging

Fig. 1

Predicting age from gene expression data. Rows from top to bottom show age prediction results for LDA Ensemble with 20-year age bins, elastic net, linear regression, and support vector regression

Some people appear to be considerably younger or older than their chronological age. Genetic signatures that may help explain this have been discovered by scientists at the Salk Institute. The age-associated genetic patterns were found by analyzing skin cells from people of various ages, according to a study by Salk Institute scientists.

Researchers then applied the results to detect genetic signs of accelerated aging in people with progeria, a disease that causes patients to appear far older than their chronological age...

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Human Blood Cells can be directly Reprogrammed into Neural stem cells


Stem cells are considered to be the all-rounders of our tissues: they can multiply indefinitely and then — if they are pluripotent embryonic stem cells — generate all conceivable cell types.
Credit: © M.C. Thier/DKFZ

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

Stem cells are considered to be the all-rounders of our tiss...

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Exposure to Cannabis Alters the Genetic Profile of Sperm


“There’s something about cannabis use that affects the genetic profile in sperm. We don’t yet know what that means, but the fact that more and more young males of child-bearing age have legal access to cannabis is something we should be thinking about.”
— Scott Kollins, Ph.D.

Whether genetic changes can be reversed or are passed on to children is still unknown. New research from Duke Health suggests men in their child-bearing years should also consider how THC could impact their sperm and possibly the children they conceive during periods when they’ve been using the drug...

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Getting the most out of Spinach: Maximizing the Antioxidant Lutein

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Liberation of lutein from spinach: Effects of heating time, microwave-reheating and liquefactionFood Chemistry, 2019; 277: 573 DOI: 10.1016/j.foodchem.2018.11.023

Eat your spinach in the form of a smoothie or juice – this is the best way to obtain the antioxidant lutein, according to research from Linköping University, Sweden. High levels of lutein are found in dark green vegetables, and researchers at the university have compared different ways of preparing fresh spinach in order to maximise the levels of lutein in finished food. The findings are published in the journal Food Chemistry.

Many people with atherosclerosis (narrowing of the arteries) have low-grade, chronic inflammation that can be measured in the blood...

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