Category Biology/Biotechnology

Spleen-based islet transplantation restores glycemic control in type 1 diabetes without full immunosuppression

Spleen-based islet transplantation restores glycemic control without full immunosuppression
Human islets grown in the immune-remodeled spleen of macaques. Credit: Lei Dong/Nanjing University and Jian Xiao/Wenzhou Medical University

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression. Nanoparticle-driven spleen remodeling allowed transplanted mouse, rat, and human islets to restore normal blood sugar in diabetic rodents and cynomolgus macaques.

In type 1 diabetes, the immune system destroys native beta cells, the insulin-producing cells housed within pancreatic clusters called islets of Langerhans...

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AI outperforms humans in emotional intelligence tests, study finds

AI outperforms humans in emotional intelligence tests
Credit: AI-generated image

Is artificial intelligence (AI) capable of suggesting appropriate behavior in emotionally charged situations? A team from the University of Geneva (UNIGE) and the University of Bern (UniBE) put six generative AIs—including ChatGPT—to the test using emotional intelligence (EI) assessments typically designed for humans.

The outcome: these AIs outperformed average human performance and were even able to generate new tests in record time. These findings open up new possibilities for AI in education, coaching, and conflict management. The study is published in Communications Psychology.

Large language models (LLMs) are artificial intelligence (AI) systems capable of processing, interpreting and generating human language...

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Clinical trial shows improvements for spinal cord injuries

The leadership group for the Texas Biomedical Device Center includes, from left, Dr. Michael Kilgard, Dr. Jane Wigginton, Dr. Seth Hays and Dr. Robert Rennaker.

Researchers demonstrated unprecedented rates of recovery for spinal cord injuries. Individuals with incomplete spinal cord injury safely received a combination of stimulation of a nerve in the neck with progressive, individualized rehabilitation. This approach, called closed-loop vagus nerve stimulation (CLV), produced meaningful improvements in arm and hand function in these individuals.

In a new clinical study, researchers from the Texas Biomedical Device Center (TxBDC) at The University of Texas at Dallas demonstrated unprecedented rates of recovery for spinal cord injuries.

In this study, published in the journal Natu...

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New perspectives for wound healing and the treatment of chronic diseases

Human fibroblasts comprise diverse populations with specialized roles in tissue homeostasis and pathology that are controlled by developmental and environmental signals. Image: Professor Sandra Franz, Biorender.com

Fibroblasts are specialised connective tissue cells that play a key role in wound healing and tissue regeneration. The recent scientific publication from the University of Leipzig Medical Center shows that fibroblasts respond differently depending on the organ and disease context. Their functions are shaped by their embryonic origin, tissue-specific signals, and pathological stimuli...

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