Category Health/Medical

Off-Patent Liver Disease Drug could Prevent COVID-19 Infection and Protect against Future Variants, researchers find

Close up of bile duct/liver organoid infected with SARS-CoV-2 – red indicates the virus. (Credit: Teresa Brevini)

Unique experiments involved ‘mini-organs’, animal research, donated human organs, volunteers and patients. Cambridge scientists have identified an off-patent drug that can be repurposed to prevent COVID-19 — and may be capable of protecting against future variants of the virus — in research involving a unique mix of ‘mini-organs’, donor organs, animal studies and patients.

The research, published today in Nature, showed that an existing drug used to treat a type of liver disease is able to ‘lock’ the doorway by which SARS-CoV-2 enters our cells, a receptor on the cell surface known as ACE2...

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Do Women Age differently from Men?

Rapamycin prolongs lifespan only in female fruit flies.
© K. Link

The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in Cologne and University College London have now shown. They report in Nature Aging that the drug only prolongs the lifespan of female fruit flies, but not that of males.

In addition, rapamycin only slowed the development of age-related pathological changes in the gut in female flies. The researchers conclude that the biological sex is a crucial factor in the effectiveness of anti-aging drugs.

The life expectancy of women is significantly higher than that of men...

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Machine Learning Model builds on Imaging Methods to better Detect Ovarian Lesions

ultrasound images or a benign and a malignant lesion using Zhu's new technique
(From left) The top row shows an ultrasound image of a malignant lesion, the blood oxygen saturation, and hemoglobin concentration. The bottom row is an ultrasound image of a benign lesion, the blood oxygen saturation, and hemoglobin concentration. (Image: Zhu lab)

New research yields a novel method to use ultrasound to enhance machine learning’s ability to accurately diagnose — or rule out — ovarian cancer.

Although ovarian cancer is the deadliest type of cancer for women, only about 20% of cases are found at an early stage, as there are no real screening tests for them and few symptoms to prompt them...

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Team creates Nano-Magnets that could Restore Damaged Nerve Cells

The nano-magnets that will restore damaged nerve cells
Modular magnetic devices for applying local magnetic fields. Applying magnetic fields using A) 4 mm diameter pinhole parallelly-aligned and beehive-like magnetic devices. B) 1.5 cm diameter ring magnet. i) Illustrations of magnetic devices. In blue: pores are arranged in a beehive-like pattern, in red: pores are arranged in parallel lines. ii) Life-size images of magnetic rod/ring. iii) Simulations of magnetic flux density in COMSOL software. The images present a top view of magnetic flux density generated by a magnetic rod/ring in tesla (T). Intensity is color-coded (low intensity in dark blue, high intensity in red). iv) COMSOL simulations of magnetic field, magnetic flux density, and magnetic force 1 mm above the magnetic rod/ring. The magnetic field is indicated as solid lines...
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