Category Health/Medical

Dietary Change Starves Cancer Cells, Overcoming Treatment Resistance

Blue green cell microscopic amino
Green staining shows mTORC1 is significantly increased due to disruption in GATOR1 in a mouse model of colon cancer. Credit: Sumeet Solanki, Ph.D.

Laboratory research finds a low-protein diet can enhance standard treatment for colon cancer. A dietary change could be a key to enhancing colon cancer treatment, a new study from the University of Michigan Rogel Cancer Center finds.

Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1.

While mTORC1 is known to be hyperactive in colon cancer, the k...

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New Study identifies Connection between Diabetes Medications, Multiple Sclerosis

A new study found that anti-hyperglycemic medications used to treat Type 2 diabetes resulted in an increased risk of multiple sclerosis for people older than 45, particularly among women.

A new University of Arizona Health Sciences study found that people older than 45yo whose Type 2 diabetes was treated with anti-hyperglycemic medications had an increased risk of multiple sclerosis, particularly among women, while anti-hyperglycemic exposure in people younger than 45 reduced that risk.

“Our findings reinforce the need for a precision medicine approach to preventing MS in these vulnerable populations,” said lead researcher Kathleen Rodgers, PhD, associate director of translational neuroscience at the Center for Innovation in Brain Science.

Multiple sclerosis (MS) is an unpredicta...

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Powerhouses of the Cells: Mitochondria have a Waste Disposal Mechanism to get rid of Mutated mtDNA

Electron micrograph of nucleoid extraction in a cell and schematic representation of the new mechanism. Copyright: David Pla-Martin

A research team has identified a molecular target that could open up new therapeutic options to treat aging-associated diseases like Parkinson’s. Scientists at the University of Cologne have discovered how cells can eliminate mutated mitochondrial DNA (mtDNA). Mitochondria are the powerhouses of our cells. Due to their evolutionary descent from bacteria, they still have genetic material packaged in chromosome-like structures (nucleoids). They convert the chemical energy in our food into a biologically usable form...

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Gossypetin found in Hibiscus may Beat Alzheimer’s disease

A Cup of ruby red hibiscus tea not only warms the body in winter but also is known to boost the immune system, control blood pressure, and reduce body weight. And here is yet another reason to enjoy this tea – It may defeat Alzheimer’s disease.

Professor Kyong-Tai Kim and PhD candidate Kyung Won Jo (Department of Life Sciences) at POSTECH has verified that the gossypetin found in hibiscus activates microglia, the resident immune cell in the brain. The research team also demonstrated that microglia scavenge amyloid-beta (Aβ) in the brain to ameliorate cognitive impairments brought on by Alzheimer’s disease (AD).

AD begins as Aβ and Tau protein aggregates form deposits in the brain tissue. Microglia internalize such aggregates (phagocytosis) to protect the brain...

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