Category Health/Medical

Research in Mice shows how Diet Alters Immune System Function through a Gut Microbe

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Research in mice demonstrates how diet alters a gut microbe molecule that, in turn, prompts immune cells to downregulate inflammation. The study elucidates molecular mechanism behind long-standing belief that diet, microbiota, and immunity influence one another in myriad ways. If affirmed in larger animals and humans, the findings could inform the design of small-molecule drugs that regulate immune response to treat inflammatory conditions.

The cliché “you are what you eat” has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

The work, conducte...

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New approach provides Potential Vaccine and Treatment for Alzheimer’s

A A surface representation of the TAP01 antibody paratope, with the VH and VK domains coloured cyan and green respectively, and the individual complementary determining regions (CDR) highlighted. The conformation and location of the bound AβpE3-14 peptide is shown as a white sticks representation of its covalent structure. B The striking pseudo β-hairpin conformation of the TAP01 bound pE3-14 peptide, which is shown as a covalent sticks representation with stabilising intramolecular hydrogen bonds highlighted. C A detailed view of the TAP01-AβpE3-14 interface, with the bound peptide and interacting antibody residues shown as covalent sticks. TAP01 residues are shown in cyan and green for the VH and VK domains, respectively...
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Diet Trumps Drugs for Anti-Aging and Good Metabolic Health

A study comparing the impact of diet versus drugs on the inner workings of our cells has found nutrition has a much stronger impact.

The pre-clinical study by the University of Sydney’s Charles Perkins Centre suggests the makeup of our diet could be more powerful than drugs in keeping conditions like diabetes, stroke and heart disease at bay.

Conducted in mice, the research showed nutrition (including overall calories and macronutrient balance) had a greater impact on ageing and metabolic health than three drugs commonly used to treat diabetes and slow down ageing.

The findings are published in Cell Metabolism.

The research builds on the team’s pioneering work in mice and humans demonstrating the protective role of diet and specific combinations of proteins, fats and carbo...

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Innovative Fabric enables Digital Communication between Wearers, Nearby Devices

Innovative fabric enables digital communication between wearers, nearby devices
Assistant Professor Electrical Engineering and Computer Science Peter Tseng and Amir Hossein Haji Aghajani Memar Doctoral Student. Credit: Steve Zylius/UCI

Imagine your car starting the moment you get in because it recognizes the jacket you’re wearing. Consider the value of a hospital gown that continuously measures and transmits a patient’s vital signs. These are just two applications made possible by a new “body area network”-enabling fabric invented by engineers at the University of California, Irvine.

In a paper published recently in Nature Electronics, researchers in UCI’s Henry Samueli School of Engineering detail how they integrated advanced metamaterials into flexible textiles to create a system capable of battery-free communication between articles of clothing and nearby de...

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