Category Health/Medical

Sweet! How Glycogen is linked to Heat Generation in Fat Cells

Artistic rendering of a brown fat cell with nucleus in pink, mitochondria in purple and yellow lipid droplets scattered throughout. Image courtesy of Scientific Animations.

Researchers describe how energy expenditure and heat production are regulated in obesity through a previously unknown cellular pathway. Humans carry around with them, often abundantly so, at least two kinds of fat tissue: white and brown. White fat cells are essentially inert containers for energy stored in the form of a single large, oily droplet. Brown fat cells are more complex, containing multiple, smaller droplets intermixed with dark-colored mitochondria — cellular organelles that give them their color and are the “engines” that convert the lipid droplets into heat and energy.

Some people also have “beige”...

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Specific Molecular Mechanism that controls the Transition from Acute to Chronic Pain

Daniele Piomelli
UCI School of Medicine
“This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain,” said Daniele Piomelli, PhD, Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology.

Previously unrecognized control point identified as target for drugs that block transition. A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.

Findings from the study, titled “NAAA-regulated lipid signaling gov...

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Increased Consumption of Whole Grains could significantly Reduce the Economic Impact of Type 2 Diabetes

Increased consumption of whole grain foods could significantly reduce the incidence of type 2 diabetes and the costs associated with its treatment in Finland, according to a recent study by the University of Eastern Finland and the Finnish Institute for Health and Welfare. The findings were published in Nutrients.

“Our study shows that already one serving of full grains as part of the daily diet reduces the incidence of type 2 diabetes at the population level and, consequently, the direct diabetes-related costs, when compared to people who do not eat whole grain foods on a daily basis. Over the next ten years, society’s potential to achieve cost savings would be from 300 million (-3.3%) to almost one billion (-12...

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Chip-Based Optical Tweezers Levitate Nanoparticles in a Vacuum

Schematic of optically levitating a nanoparticle with a metalens in a vacuum. The metalens focuses a laser beam to create chip-based optical tweezers.
Credit: Kunhong Shen, Purdue University

Metalens-based design shrinks footprint, making optical traps practical for precision sensing and measurements.

Researchers have created tiny chip-based optical tweezers that can be used to optically levitate nanoparticles in a vacuum. Optical tweezers — which employ a tightly focused laser beam to hold living cells, nanoparticles and other objects — can be used for a variety of precision measurements and sensing applications. However, these optical traps are usually produced with bulky optical components.

“By using an ultrathin metalens, we reduced the diameter of the focusing lens from about...

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