Category Health/Medical

High Cholesterol Fuels Cancer by Fostering Resistance to a form of Cell Death

The proposed model to explain how cancer cells respond to 27HC treatment. Acute (left) treatment with 27HC disrupts lipid metabolism via interfering with SREBPs and LXR signaling, and this results in the inhibition of cell growth and migration. Cancer cells can adapt to the metabolic stress imposed by chronic treatment by 27HC (right). The cells that survive (27HC resistant cells) increase lipid uptake and accommodate the metabolic stress associated with this activity by upregulating the activity of processes that allow them to withstand lipid oxidative stress (ferroptosis); an activity which confers upon them enhanced tumor growth and metastatic capabilities. Numerical source data are reported in the Source Data File.

Chronically high cholesterol levels are known to be associated with...

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Eyes provide peek at Alzheimer’s Disease Risk

Amyloid deposits tagged by curcumin fluoresce in a retinal scan. Photo credit: NeuroVision

Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death. They are considered a hallmark of Alzheimer’s disease (AD), and the focus of multiple investigations designed to reduce or prevent their formation, including the nationwide A4 study.

But amyloid deposits may also occur in the retina of the eye, often in patients clinically diagnosed with AD, suggesting similar pathologies in both organs...

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Smallest Biosupercapacitor provides Energy for Biomedical Applications

A research team from Chemnitz University of Technology, IFW Dresden and IPF Dresden present a biocompatible energy storage device in the current issue of Nature Communications. In the picture: An array of 90 tubular nano-biosupercapacitors (nBSCs) on the fingertip enable autarkic operation of sensors in blood. Photo: Research Group Prof. Dr. Oliver G. Schmidt

The miniaturization of microelectronic sensor technology, microelectronic robots or intravascular implants is progressing rapidly. However, it also poses major challenges for research. One of the biggest is the development of tiny but efficient energy storage devices that enable the operation of autonomously working microsystems — in more and more smaller areas of the human body for example...

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Can Isometric Resistance Training Safely Reduce High Blood Pressure?

Dr Matthew Jones said it was exciting to know such a simple intervention could have such a strong effect on reducing blood pressure – the leading risk factor for mortality, globally. Photo: Unsplash

When was the last time you had your blood pressure checked? High blood pressure affects 1.13 billion people around the globe and in 2019, it accounted for 10.8 million deaths. Worldwide, it’s the leading risk factor for mortality. More than a third of the Australian population over the age of 18 has high blood pressure, yet it’s estimated 50 per cent of Australians don’t realise they’re living with it.

As high blood pressure puts you at high risk of having a heart attack or stroke (cardiovascular disease), it’s important to keep track of your blood pressure...

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