Category Health/Medical

Microneedle Patch delivers Antibiotics Locally in the Skin

Fingers holding the microneedle patch
The microneedles are so small that they do not reach the pain receptors, making the treatment relatively painless. Photo: Jill Ziesmer

MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers at Karolinska Institutet in Sweden are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results published in Advanced Materials Technologies show that the microneedle patch effectively reduces MRSA bacteria in the skin.

MRSA (methicillin resistant Staphylococcus aureus) skin infections are potentially lethal, especially in patients with compromised immune systems...

Read More

In fight against COVID Variants some firms Target Tcell Jabs

covid-19
Credit: Unsplash/CC0 Public Domain

Getting COVID vaccines into the arms of the world’s population is an international priority—but will today’s jabs stay effective against virus variants that are spreading across the globe?

It is one of the big questions about the pandemic, with Pfizer chief Albert Bourla recently acknowledging that it is likely a booster will be needed to help extend the protection conferred by its vaccine and ward off new variants.

A recent study presented a mixed picture. It found that the antibody response of current vaccines could fail against variants. However, a second immune response in the form of killer T cells—which attack already infected cells and not the virus itself—remained largely intact.

Several startups are working on developing shots ...

Read More

Artificial Intelligence makes great Microscopes better than ever

Green streaks shoot off of a blue, purple and pink bulbous shape against a dark background of circles and curvy lines.
A representation of a neural network provides a backdrop to a fish larva’s beating heart. Illustration credit: Tobias Wüstefeld.

Machine learning helps some of the best microscopes to see better, work faster, and process more data. Collaboration between deep learning experts and microscopy experts leads to an significantly improved data-intensive light-field microscopy method by using AI and ground-truthing it with light-sheet microscopy. The result is the power of light-field microscopy available to biologists in near real time vs. days or weeks, AND the expansion of biologists’ ability to use this microscopy for many things more things requiring the most detailed observation.

To observe the swift neuronal signals in a fish brain, scientists have started to use a technique calle...

Read More

Research Breakthrough in the Fight Against Cancer

The advantage of PACs over other therapies.
The advantage of PACs over other therapies. Courtesy: S. Thai Thayumanavan

Latest advance in targeted delivery of therapeutic proteins. A team of researchers at the Center for Bioactive Delivery at the University of Massachusetts Amherst’s Institute for Applied Life Sciences has engineered a nanoparticle that has the potential to revolutionize disease treatment, including for cancer. This new research, which appears today in Angewandte Chemie, combines two different approaches to more precisely and effectively deliver treatment to the specific cells affected by cancer.

Two of the most promising new treatments involve delivery of cancer-fighting drugs via biologics or antibody-drug conjugates (ADCs). Each has its own advantages and limitations...

Read More