Category Health/Medical

Bacterial enzyme and nanoparticle discoveries hold promise for treating gut pain

Fluorescent nanoparticles (purple) carrying a drug to treat pain accumulate in the cells of a mouse colon. Credit: Bunnett Lab

Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome. In an effort to develop targeted treatments for gut pain, scientists have discovered a new enzyme in gut bacteria and are using nanoparticles to deliver drugs inside cells.

Currently, there are no treatments specifically for gut pain, and existing painkillers are often insufficient at managing symptoms. These drugs—including opioids, NSAIDs, and steroids—also come with side effects, some of which directly harm the digestive system.

In two new studies published in Cell Host & Microbe and Proceedings of the National Academy of Sci...

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Scientists reverse Alzheimer’s in mice using nanoparticles

Left-hand image:  Light sheet fluorescence microscope images of mouse brain 12h after NOT being treated with nanoparticles. The brains were analyzed to see the amount of Aβ plaques accumulation. Red: Aβ plaques. Green: vessels from the blood brain barrier. Right-hand image: Light sheet fluorescence microscope image of mouse brain 12h after being treated with nanoparticles. The brains were analyzed to see the amount of Aβ plaques accumulation. Red: Aβ plaques. Green: vessels from the blood brain barrier.

A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in mice.

Unlike traditional nanomedici...

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Novel antibiotic targets IBD—and AI predicted how it would work before scientists could prove it

Two researchers pose in a university laboratory.
McMaster graduate student Denise Catacutan (left) and assistant professor Jon Stokes (right) have discovered a new antibiotic — and they leveraged cutting-edge AI to determine how it works.

Researchers at McMaster University and the Massachusetts Institute of Technology (MIT) have made two scientific breakthroughs at once: they not only discovered a brand-new antibiotic that targets inflammatory bowel diseases (IBD), but also successfully used a new type of AI to predict exactly how the drug works. To their knowledge, this is a global first for the AI.

Detailed in the journal Nature Microbiology, the discovery unveils a promising new treatment option for millions of people affected by Crohn’s disease and other related conditions, while also showcasing important new applications fo...

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Prediabetes remission possible without dropping pounds, new study finds

<span   " href="https://www.shutterstock.com/image-photo/beautiful-overweight-woman-running-outdoors-fitness-1549708925" rel="nofollow noopener" target="_blank" data-ylk="slk:New Africa/Shutterstock.com;elm:context_link;itc:0;sec:content-canvas">New Africa/Shutterstock.com</a></span>
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There’s a long-held belief in diabetes prevention that weight loss is the main way to lower disease risk. Our new study challenges this.

For decades, people diagnosed with prediabetes—a condition affecting up to one in three adults depending on age—have been told the same thing by their doctors: eat healthily and lose weight to avoid developing diabetes.

This approach hasn’t been working for all. Despite unchanged medical recommendations for more than 20 years, diabetes prevalence continues rising globally. Most people with prediabetes find weight-loss goals hard to reach, leaving them discouraged and still at high risk of diabetes.

Our latest research, published in Nature Medicine, reveals a different approach entirely...

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