Category Health/Medical

Chemical Compounds in Foods can Inhibit a key SARS-CoV-2 Enzyme, study finds

Photo of muscadine grapes on the vine.
Chemical compounds in muscadine grapes effectively inhibit an important SARS-CoV-2 protease. Photo courtesy of De-Yu Xie, NC State University.

Chemical compounds in foods or beverages like green tea, muscadine grapes and dark chocolate can bind to and block the function of a particular enzyme, or protease, in the SARS-CoV-2 virus, according to a new study by plant biologists at North Carolina State University.

Proteases are important to the health and viability of cells and viruses, says De-Yu Xie, professor of plant and microbial biology at NC State and the corresponding author of the study. If proteases are inhibited, cells cannot perform many important functions — like replication, for example.

“One of our lab’s focuses is to find nutraceuticals in food or medicinal plants tha...

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Researchers unlock the door to Tumor Microenvironment for CAR T cells

t cell
Credit: CC0 Public Domain

The labyrinth of jumbled blood vessels in the tumor microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumors. Now, in a new study published online today in Nature Cancer, Penn Medicine researchers found that combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack the tumor, leading to significantly enhanced survival in mice.

The researchers discovered in laboratory experiments that vascularization in solid tumors is driven by the genetic reprogramming of tumor endothelial cells—which line the walls of blood vessels—caused by an enzyme known as PAK4...

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New insights on Health effects of Long-duration Space Flight

snow-capped peaks of the Andes Mountains, seen from the International Space Station
The snow-capped peaks of the Andes Mountains in southern Chile are pictured from the International Space Station as it orbited above South America in November 2020. Photo: National Aeronautics and Space Administration

Among the new findings, the research team found that chronic oxidative stress during spaceflight contributed to the telomere elongation they observed. They also found that astronauts had shorter telomeres after spaceflight than they did before.

The historic NASA Twins Study investigated identical twin astronauts Scott and Mark Kelly and provided new information on the health effects of spending time in space.

Colorado State University Professor Susan Bailey was one of more than 80 scientists across 12 universities who conducted research on the textbook experiment; M...

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Aim to Exceed Weekly Recommended Physical Activity level to Offset health harms of prolonged Sitting

Aim to exceed weekly recommended physical activity level to offset health  harms of prolonged sitting, says WHO - FarmWeek

First recommendation of its kind in new global guidelines on physical activity and sedentary behavior. New additional research shows that increasing physical activity can counter early death risk linked to long periods of sedentary time

The health harms associated with prolonged sitting can be offset by exceeding weekly recommended physical activity levels, says the World Health Organization (WHO) in new global guidelines on physical activity and sedentary behaviour, published in a special dedicated issue of the British Journal of Sports Medicine.

But all physical activity counts and is good for long term health, say the new guidelines.

It’s the first time that a recommendation of this kind has been made...

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